Sharma, ShubhamSingh, VirenderVaishaliKumar, RakeshJamra, RahulBanyal, NaveenJyoti2024-01-212024-08-132024-01-212024-08-132023-11-250022152X10.1002/jhet.4758http://10.2.3.109/handle/32116/3296The synthesis of pyrazole derivative using ?,?-unsaturated carbonyl compounds has attracted increasing attention of the synthetic organic chemist community. Interestingly, the simplicity of the synthetic method, high reactivity, and ease of incorporating diversity into the desired prototype have contributed a lot toward the exploration of ?,?-unsaturated carbonyl compounds by various research groups. Due to the tremendous pharmacological significance of pyrazole derivatives, their synthesis has been one of the leading research frontiers in recent years. As prime examples, sildenafil, zometapin, Celebrex, and rimonabant have been successfully commercialized in the market to treat various life-challenging diseases. Considering the great profile of ?,?-unsaturated carbonyl compound in the synthesis of biologically active pyrazole derivatives, this review incorporates contemporary literature (2011�2022) on the synthesis of pyrazole and its derivatives using ?,?-unsaturated carbonyl compound as a starting precursor. � 2023 Wiley Periodicals LLC.en-USReviewhttps://onlinelibrary.wiley.com/doi/10.1002/jhet.4758