Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Imamura, M.Takahashi, A.Yamauchi, T.Hara, K.Yasuda, K.Grarup, N.Zhao, W.Wang, X.Huerta-Chagoya, A.Hu, C.Moon, S.Long, J.Kwak, S.H.Rasheed, A.Saxena, R.Ma, R.C.W.Okada, Y.Iwata, M.Hosoe, J.Shojima, N.Iwasaki, M.Fujita, H.Suzuki, K.Danesh, J.J?rgensen, T.J?rgensen, M.E.Witte, D.R.Brandslund, I.Christensen, C.Hansen, T.Mercader, J.M.Flannick, J.Moreno-Mac?as, H.Burtt, N.P.Zhang, R.Kim, Y.J.Zheng, W.Singh, J.R.Tam, C.H.T.H2018-07-142024-08-142018-07-142024-08-142016Imamura, M., Takahashi, A., Yamauchi, T., Hara, K., Yasuda, K., Grarup, N., . . . Kadowaki, T. (2016). Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nature Communications, 7. doi: 10.1038/ncomms105312041172310.1038/ncomms10531https://kr.cup.edu.in/handle/32116/1340Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 ? 10-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities. ? 2016, Nature Publishing Group. All rights reserved.enDiabetesEthnic GroupGenetic AnalysisHealth RiskHeritabilityMeta-Analysis Asb3 GeneAtp8B2 GeneCcdc85A GeneDmrta1 GeneEthnic GroupFam60A GeneGeneGene LocusGenetic AssociationGenetic SusceptibilityGenotypeHumanInafm2 GeneJapanese (People)Major Clinical StudyMeta AnalysisMir4686 GeneNon Insulin Dependent Diabetes MellitusSingle Nucleotide PolymorphismAsian Continental Ancestry GroupCase Control StudyGenetic PredispositionGeneticsGenomGenome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetesArticlehttps://www.nature.com/articles/ncomms10531Nature Communications