Handa, MayankKumar, KamleshGarabadu, DebapriyaKushawaha, Pramod KumarShukla, Rahul2024-01-212024-08-142024-01-212024-08-142023-02-072041599010.4155/tde-2022-0043http://10.2.3.109/handle/32116/4358Aim: In the present work, fixed-dose combination of bilayer tablets for piroxicam as and curcumin as immediate-release and sustained-release layer (SRL) respectively for management of inflammatory response. Materials & methods: The SRL include Curcumin polycaprolactone microparticles from spray drying. The tablet layers include Pearlitol 200SD, Microcrystalline cellulose PH101, Aerosil 200, talc each layer. Results: SEM studies confirm spherical microparticles. PXRD and DSC studies confirm the amorphous microparticles. In vitro studies exhibit, an immediate release and sustained release for Piroxicam and Curcumin after 2 h. Cellular uptake studies on RAW 264.7 cells confirm the complete internalization of microparticles. Conclusion: Therefore, it was concluded that microparticles can be formulated into a unit dosage form for the management of inflammation. � 2023 Newlands Press.en-USbilayer tabletcurcuminfixed-dose combinationpiroxicamreleasespray dryingArticlehttps://www.future-science.com/doi/10.4155/tde-2022-0043