Kaur, Sukhvir2018-08-312024-08-142018-08-312024-08-142018Kaur, Sukhvir (2018) Association of COX-2 (rs20417) polymorphism with aspirin resistance and adverse drug reactions (if any) in ischemic stroke patients in Malwa region of Punjab.https://kr.cup.edu.in/handle/32116/1894Ischemic stroke pathology involves the formation of a thrombus over an unstable atherosclerotic plaque through various inflammatory and clotting cascades. Aspirin is the oldest antiplatelet agent with well-established efficacy in stroke prevention. COX2 gene with rs20417 polymorphism has been found to be associated with ischemic stroke as well as aspirin resistance. We aimed to study the demographic profile of ischemic stroke patients from Malwa region of Punjab and check the frequency of rs20417 variant of COX 2 gene and correlate it with aspirin resistance and ADRs (if any) in ischemic stroke patients. We collected 30 samples from confirmed stroke patients from Malwa region of Punjab. DNA was isolated from blood and subjected to PCR and RFLP to evaluate rs20417 in COX 2 gene in the patients. Their mRS score was used to classify patients as aspirin responders or aspirin non-responders. 96.66% patients were aspirin responders and 3.33% were non-responders. Twenty-nine patients were carriers of CC genotype, of which 27 were responders and 2 were non-responders. Only 1 patient with CG genotype was a non-responder. A larger number of samples need to be screened for the COX-2 G765C polymorphism before coming to a conclusion. This preliminary study indicates that COX-2 G765C variant of COX-2 gene may not be a risk factor for aspirin resistance in ischemic stroke patients from Malwa region of Punjaben-USIschemic StrokeAspirinAspirin ResistanceCox 2 GeneRs20417 VariantMaster DissertationT00673