Kumar, SachinKumar, MandeepBijalwan, AnjaliSharma, ShubhamKumar, Puneet2024-01-212024-08-142024-01-212024-08-142022-09-289789811654220978981165421310.1007/978-981-16-5422-0_267http://10.2.3.109/handle/32116/4339Incremental elevation in the trends of a brain tumor in recent years accounts for 5% adult population, whereas the number exceeds 70% in the case of children. Evidence reveals an eventual metastasize of 20%-30% of malignant tumors to the brain�s different regions. Compression in the brain tissue and elevated intracranial pressure mediated by benign and malignant tumors contributed to severe consequences like the central nervous system (CNS) damage or even imperil the patient�s life. Despite multiple therapeutic strategies in the market, none of the drugs are fully effective and safe. Strategic advancement indicates chemotherapy as a treatment of choice for critical conditions like brain tumors, but the chemotherapy drugs toxicity is still a major therapeutic hurdle. Plants and their derived natural products are one of the most emerging targets to strike against brain tumors. Analogs of several natural products are already demonstrated as antitumor in nature, and day by day, advancements unfold various other plant and plant derivatives having such antitumor activity. This chapter aims to underline and emphasize the antitumor agents, which can target brain tumors procured from the natural origin such as natural products and their analogs. The available data on different plants and isolated compounds of natural origin used to reduce and arrest brain tumors is also discussed here. � Springer Nature Singapore Pte Ltd. 2022.en-USAlkaloidsAnticancer agentsBrain tumorCancer stem cellsFlavonoidsNatural productsRisk factorsBook chapterhttps://link.springer.com/10.1007/978-981-16-5422-0_267