Arora, AnchalNavik, Uma ShankerJaiswal, AiswaryaKaur, PrabhsharanKumar, Puneet2024-01-212024-08-142024-01-212024-08-142021-03-2497815361945319781536191776http://10.2.3.109/handle/32116/4289Diabetes is a chronic illness characterized by uncontrolled hyperglycemia, disturbances in carbohydrate, and lipid and protein metabolism due to impaired function of insulin-secreting pancreatic ?-cell, insulin action or both. If not treated on time diabetes patients are more prone to developing secondary complications such as microvascular complications, including nephropathy, retinopathy, neuropathy, diabetic foot, dermopathy, and macrovascular complications like coronary arteries disease, peripheral arterial disease, stroke and cardiomyopathy. This increases the co-morbidity and mortality rate among diabetes patients. Therefore, hyperglycemia management could be of profound clinical significance to reduce the rate of complications of diabetes. Further, hyperglycemia results in the activation of multiple abnormal signaling pathways that poses more complex diabetes pathology resulting in end-organ damage. Traditionally, the available approved therapy, such as insulin and sulphonylureas, possesses side effects such as weight gain and hypoglycaemic shock. Therefore developing a novel therapy for targeting complex pathways for mitigating diabetes complications is highly appreciable. Hence, this chapter aims to discuss the novel therapeutic approaches for treating diabetes complications with their mechanism of action. � 2021 Nova Science Publishers, Inc.en-USDiabetes mellitusHyperglycaemiaNovel treatmentsSecondary complicationsBook chapterhttps://novapublishers.com/shop/diabetes-and-diabetic-complications-current-status-and-future-perspectives/