Hassan, Muhammad AamirKhan, Aqib ZafarSajid, Muhammad MunirJaved, YasirUllah, AsmatShad, Naveed AkhtarSharma, Surender K.Shafique, MuhammadSarwar, Muhammad2024-01-212024-08-132024-01-212024-08-132021-10-292364329310.1007/978-3-030-79960-1_5http://10.2.3.109/handle/32116/3689Nanotechnology has introduced new techniques and therapeutic approaches for the treatment of different cancer types. Current cancer-curing drugs have many limitations such as use of high concentrations, effects on other cells, and non-confinement at cancer sites, which reduce the efficacy of drugs and also induce toxic effects in other normal cells. Nanomaterials have provided new ways to increase the efficacy of already used cancer drugs by providing drug delivery systems. Anticancer drugs can be encapsulated/attached with the nanomaterials and delivered at specific sites and cells under certain microenvironment conditions. Among metallic oxide nanoparticles, iron-based particles have shown great potential in drug delivery and at the same time for cancer treatment by producing localized heat. Therefore, researchers have focused on iron oxide nanoparticles as drug delivery vehicles. This chapter highlights the synthesizing methods of iron oxide nanoparticles such as co-precipitation, thermal decomposition, microemulsion, sol�gel, and additional chemical methods including hydrothermal, sonochemical decomposition, and electrochemical for their wide range of biomedical applications. It also provides a brief overview of recent developments in iron oxide nanoparticles, some limitations in the explored research areas. and suggests future directions to overcome these limitations. � 2021, Springer Nature Switzerland AG.en-USAntibodiesBiocompatibilityDrug deliveryIron oxide nanoparticlesSurface modificationConference paperhttps://link.springer.com/10.1007/978-3-030-79960-1_5