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dc.contributor.authorBaviskar, Ashish T.
dc.contributor.authorBanerjee, Uttam C.
dc.contributor.authorGupta, Mukesh
dc.contributor.authorSingh, Rajveer
dc.contributor.authorKumar, Sunil
dc.contributor.authorGupta, Manish K.
dc.contributor.authorKumar, Sanjeev
dc.contributor.authorRout, Satish K.
dc.contributor.authorKhullar, Madhu
dc.contributor.authorSingh, Sandeep
dc.contributor.authorKumar, Raj
dc.date.accessioned2017-12-29T05:03:37Z
dc.date.available2017-12-29T05:03:37Z
dc.date.issued2013
dc.identifier.citationBaviskar, A. T., Banerjee, U. C., Gupta, M., Singh, R., Kumar, S., Gupta, M. K., . . . Kumar, R. (2013). Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity. Bioorganic and Medicinal Chemistry, 21(18), 5782-5793. doi: 10.1016/j.bmc.2013.07.016en_US
dc.identifier.issn9680896
dc.identifier.urihttp://kr.cup.edu.in/handle/32116/403
dc.description.abstractDesign, synthesis and anticancer activity of a series of imine-pyrazolopyrimidinones is reported for the first time. Compounds 9d, 9n and 9o in the series show encouraging in vitro anticancer activity with low micromolar IC50 values against prostate (PC3) and breast (MCF7) cancer cell lines. Some notions about structure-activity relationships and plausible mechanism of biological activity are presented. ? 2013 Elsevier Ltd. All rights reserved.en_US
dc.language.isoenen_US
dc.subject5 (2 chlorobenzylideneamino) 1 benzyl 6,7 dihydro 6 (2 chlorophenyl) 1h pyrazolo[3,4 d]pyrimidin 4 (5h)oneen_US
dc.subject5 (3 methoxy 4 hydroxybenzylideneamino) 1 benzyl 1h pyrazolo[3,4 d]pyrimidin 4 (5h)oneen_US
dc.subject5 (4 methoxybenzylideneamino) 1 benzyl 6,7 dihydro 6 (4 methoxyphenyl) 1h pyrazolo[3,4 d]pyrimidin 4 (5h)oneen_US
dc.subjectAntineoplastic agenten_US
dc.subjectEtoposideen_US
dc.subjectImine pyrazolopyrimidinoneen_US
dc.subjectPyrimidinone derivativeen_US
dc.subjectUnclassified drugen_US
dc.subjectAntineoplastic activityen_US
dc.subjectAntiproliferative activityen_US
dc.subjectArticleen_US
dc.subjectCell cycle progressionen_US
dc.subjectConen_US
dc.titleSynthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activityen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bmc.2013.07.016
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0968089613006275?via%3Dihub
dc.title.journalBioorganic and Medicinal Chemistry


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