Ganoderic acid, lanostanoid triterpene: a key player in apoptosis
View/ Open
Date
2018Author
Gill, Balraj Singh
Navgeet
Mehra, Richa
Kumar, Vicky
Kumar, Sanjeev
Metadata
Show full item recordAbstract
Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell death determines the fate of a cell, which might progress towards survival or apoptosis. Apoptosis is a complex, programmed, and highly regulated process causing dramatic morphological and biochemical perturbations in the cellular machinery. Ganoderma lucidum is a basidiomycetes, polypore mushroom known for its pharmacological properties in cancer. The major bioconstituents in G. lucidum are terpenoids, polysaccharides, and proteins that target cancer-signaling factors like plasma membrane receptors proteins and adapter molecules. Of all constituents, the major terpenoid, i.e. Ganoderic acid is reported to interact with membrane receptors mainly, receptor tyrosine kinase (RTKs). Ganoderic acid interacts and modulates the signaling network in IR, IGFR-1, IGFR-2, VEGFR-1, VEFGR-2, and EGFR in cancer signaling pathways. It primarily targets NF-?B, RAS-MAPK, PI3K/Akt/mTOR, and cell cycle resulting in apoptosis. This review highlights the role of ganoderic acid in apoptosis and modulations of various signaling proteins in cancer. ? 2017, Springer Science+Business Media, LLC.
Journal
Investigational New Drugs
Collections
Related items
Showing items related by title, author, creator and subject.
-
PROTAC�ing oncoproteins: targeted protein degradation for cancer therapy
Kelm, Jeremy M.; Pandey, Deepti S.; Malin, Evan; Kansou, Hussein; Arora, Sahil; Kumar, Raj; Gavande, Navnath S. (BioMed Central Ltd, 2023-03-30)Molecularly targeted cancer therapies substantially improve patient outcomes, although the durability of their effectiveness can be limited. Resistance to these therapies is often related to adaptive changes in the target ... -
Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans
Kumar, N.; Jain, V.; Singh, A.; Jagtap, U.; Verma, S.; Mukhopadhyay, A. (Impact Journals LLC, 2015)Lowering insulin-IGF-1-like signalling (IIS) activates FOXO transcription factors (TF) to extend life span across species. To study the dynamics of FOXO chromatin occupancy under this condition in C. elegans, we report the ... -
Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis
Chander, Harish; Brien, Colin D; Truesdell, Peter; Kathleen, Watt; Meens, Jalna; Schick, Colleen; Germain, Doris; Craig, Andrew WB (BioMed Central Ltd., 2014)Introduction: Transducer of Cdc42-dependent actin assembly-1 (Toca-1) recruits actin regulatory proteins to invadopodia, and promotes breast tumor metastasis. Since metastatic breast tumors frequently harbor mutations in ...