Browsing by Author "Kumar, Sunil"

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    Fractional time-delay mathematical modeling of Oncolytic Virotherapy
    (Elsevier Ltd, 2021-06-19T00:00:00) Kumar, Pushpendra; Erturk, Vedat Suat; Yusuf, Abdullahi; Kumar, Sunil
    An emerging treatment tool which uses replication-competent viruses to dissipate cancers without causing deficit to normal tissues, named as oncolytic virotherapy, is discussed in the article. We analysed a fractional delay dynamical model on the oncolytic virotherapy compositing viral lytic cycle and virus-specific cytotoxic T lymphocyte (CTL) response. We used a well known Caputo fractional derivative to analyse the structure of the given dynamical model. Using the literature of fixed-point theory, the given time-delay model is specified to have existence of a unique solution. We established different types of graphical simulations for the various values of R0 and R1. We observed a different behaviour of the given fractional model as compare to the integer order model. The given algorithm is smooth in use and reliable to apply on different delay dynamical models. � 2021 Elsevier Ltd
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    Omics for Environmental Engineering and Microbiology Systems
    (CRC Press, 2022-09-09T00:00:00) Kumar, Vineet; Garg, Vinod Kumar; Kumar, Sunil; Biswas, Jayanta Kumar
    Bioremediation using microbes is a sustainable technology for biodegradation of target compounds, and an omics approach gives more clarity on these microbial communities. This book provides insights into the complex behavior of microbial communities and identifies enzymes/metabolites and their degradation pathways. It describes the application of microbes and their derivatives for the bioremediation of potentially toxic and novel compounds. It highlights the existing technologies along with industrial practices and real-life case studies. Features: � Includes recent research and development in the areas of omics and microbial bioremediation. � Covers the broad environmental pollution control approaches such as metagenomics, metabolomics, fluxomics, bioremediation, and biodegradation of industrial wastes. � Reviews metagenomics and waste management, and recycling for environmental cleanup. � Describes the metagenomic methodologies and best practices, from sample collection to data analysis for taxonomies. � Explores various microbial degradation pathways and detoxification mechanisms for organic and inorganic contaminants of wastewater with their gene expression. This book is aimed at graduate students and researchers in environmental engineering, soil remediation, hazardous waste management, environmental modeling, and wastewater treatment. � 2023 selection and editorial matter, Vineet Kumar, Vinod Kumar Garg, Sunil Kumar and Jayanta Kumar Biswas. All rights reserved.
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    Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity
    (2013) Baviskar, Ashish T.; Banerjee, Uttam C.; Gupta, Mukesh; Singh, Rajveer; Kumar, Sunil; Gupta, Manish K.; Kumar, Sanjeev; Rout, Satish K.; Khullar, Madhu; Singh, Sandeep; Kumar, Raj
    Design, synthesis and anticancer activity of a series of imine-pyrazolopyrimidinones is reported for the first time. Compounds 9d, 9n and 9o in the series show encouraging in vitro anticancer activity with low micromolar IC50 values against prostate (PC3) and breast (MCF7) cancer cell lines. Some notions about structure-activity relationships and plausible mechanism of biological activity are presented. ? 2013 Elsevier Ltd. All rights reserved.