Browsing by Author "Singh, Garima"

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Edible mushrooms: The potential game changer in alleviating vitamin D deficiency and improving human health
(John Wiley and Sons Inc, 2021-10-20T00:00:00) Tiwari, Abhay; Singh, Garima; Singh, Umesh; Sapra, Leena; Rana, Vikrant; Sharma, Vasudha; Srivastava, Rupesh K.; Sharma, Satyawati
The present review attempts to critically examine and evaluate research findings on mushrooms as sources of vitamin D and other nutraceuticals. Recently, there is a growing concern about diseases associated with the deficiency of vitamin D in humans. As people tend to stay indoors, in present times, due to the COVID-19 pandemic, vitamin D levels are further affected. Research indicates vitamin D as a promising defensive or therapeutic agent against COVID, making this review more crucial. Mushrooms, as a rich source of vitamin D along with various bioactive compounds, perform a significant role in resolving health issues. Robust analyses of various strategies for enhancing vitamin D content in mushrooms holds significance in this study; moreover, this will help stakeholders of the mushroom industry in enriching the overall mushroom quality and human health. Mushroom-based medicinal formulations and functional foods serve to deliver vitamins and nutrients to humans, thus helping to combat malnutrition and other health problems, especially in developing countries. Evidence from pre-clinical and clinical analyses suggests that vitamin D2 bioavailability in mushrooms is comparable with vitamin D from other sources. The review also emphasises molecular findings from mushrooms related to genes responsible for morphology and metabolic production of pro-vitamin-D2. � 2021 Institute of Food Science and Technology
Edible mushrooms: The potential game changer in alleviating vitamin D deficiency and improving human health
(John Wiley and Sons Inc, 2021-10-20T00:00:00) Tiwari, Abhay; Singh, Garima; Singh, Umesh; Sapra, Leena; Rana, Vikrant; Sharma, Vasudha; Srivastava, Rupesh K.; Sharma, Satyawati
The present review attempts to critically examine and evaluate research findings on mushrooms as sources of vitamin D and other nutraceuticals. Recently, there is a growing concern about diseases associated with the deficiency of vitamin D in humans. As people tend to stay indoors, in present times, due to the COVID-19 pandemic, vitamin D levels are further affected. Research indicates vitamin D as a promising defensive or therapeutic agent against COVID, making this review more crucial. Mushrooms, as a rich source of vitamin D along with various bioactive compounds, perform a significant role in resolving health issues. Robust analyses of various strategies for enhancing vitamin D content in mushrooms holds significance in this study; moreover, this will help stakeholders of the mushroom industry in enriching the overall mushroom quality and human health. Mushroom-based medicinal formulations and functional foods serve to deliver vitamins and nutrients to humans, thus helping to combat malnutrition and other health problems, especially in developing countries. Evidence from pre-clinical and clinical analyses suggests that vitamin D2 bioavailability in mushrooms is comparable with vitamin D from other sources. The review also emphasises molecular findings from mushrooms related to genes responsible for morphology and metabolic production of pro-vitamin-D2. � 2021 Institute of Food Science and Technology
Expression of KIBRA in Breast Cancer Cell Lines
(Central University of Punjab, 2018) Singh, Garima; Chander,Harish
Breast cancer the most frequently diagnosed cancer and its metastasis to distant organs accounts the majority of deaths. Numerous genes and proteins are involved in the cause of metastasis. Though KIBRA is one of the component of Hippo Pathway and is reported as tumor suppressor but this scaffolding protein has also been found to be an emerging and important player in the process of metastasis. It has been reported that KIBRA protein interacts with various proteins through its domain and leads cytoskeleton arrangement, cell polarity and migration. N terminal and C terminal of the protein contains the WW, Internal C2 & putative class III PDZ domain that interacts with DDR1, DLC1 & PKC? and helps the breast cancer cells to metastasize. To study whether KIBRA is involved in breast cancer metastasis, we checked its expression at both protein and mRNA level by Immunoblotting and Real Time PCR which showed increased KIBRA expression in ER positive cells. Further investigation to elucidate the role of KIBRA in ER positive cells, ER transfection and immunoblotting in triple negative breast cancer cell lines were performed, which indicated that ER leads to enhanced KIBRA expression in breast cancer cells.
Role of nanoparticles in the treatment of human disease: a comprehensive review
(Elsevier, 2022-12-09T00:00:00) Zomuansangi, Ruth; Singh, Bhim Pratap; Singh, Garima; Zothanpuia; Singh, Prashant Kumar; Song, Jae Jun; Kharat, Arun S.; Deka, Purbhajyoti; Yadav, Mukesh Kumar
Nanoparticles (NPs) are nanosize particles which can be employed to treat human diseases and enhance the potential of existing drugs. The NPs can overcome biological barriers and enhance the drug delivery to the target site and thus increase efficiency of the drug. NPs are classified into various types, including polymeric, inorganic, and lipid-based NPs. In addition different types of NPs are used in medical fields, such as chitosan, alginate, cellulose, and liposome-based. The NPs have offered many advantages in disease diagnostic and therapeutic with the safe delivery of the various drugs into the tissue. In the past few years, the usage of nanotechnology in medicine has led to the improvement of vaccine efficiency, immunity strategies, and targeted delivery to attain a positive immune response at the cellular level and to advance vaccine efficiency. The NP carriers should defend the antigens from premature proteolytic degradation, ease antigen uptake and processing by antigen-presenting cells, control release, and be harmless for human consumption. This review chapter presents a summary of the current research and future trends in the use of NPs in the treatment of diseases with an emphasis on drug delivery. � 2023 Elsevier Inc. All rights reserved.
Role of nanoparticles in the treatment of human disease: a comprehensive review
(Elsevier, 2022-12-09T00:00:00) Zomuansangi, Ruth; Singh, Bhim Pratap; Singh, Garima; Zothanpuia; Singh, Prashant Kumar; Song, Jae Jun; Kharat, Arun S.; Deka, Purbhajyoti; Yadav, Mukesh Kumar
Nanoparticles (NPs) are nanosize particles which can be employed to treat human diseases and enhance the potential of existing drugs. The NPs can overcome biological barriers and enhance the drug delivery to the target site and thus increase efficiency of the drug. NPs are classified into various types, including polymeric, inorganic, and lipid-based NPs. In addition different types of NPs are used in medical fields, such as chitosan, alginate, cellulose, and liposome-based. The NPs have offered many advantages in disease diagnostic and therapeutic with the safe delivery of the various drugs into the tissue. In the past few years, the usage of nanotechnology in medicine has led to the improvement of vaccine efficiency, immunity strategies, and targeted delivery to attain a positive immune response at the cellular level and to advance vaccine efficiency. The NP carriers should defend the antigens from premature proteolytic degradation, ease antigen uptake and processing by antigen-presenting cells, control release, and be harmless for human consumption. This review chapter presents a summary of the current research and future trends in the use of NPs in the treatment of diseases with an emphasis on drug delivery. � 2023 Elsevier Inc. All rights reserved.