Department Of Chemistry
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Item An Overview on Biological Evaluation of Tetrazole Derivatives(Springer Nature, 2022-03-07T00:00:00) Kabi, Arup K.; Sravani, Sattu; Gujjarappa, Raghuram; Garg, Aakriti; Vodnala, Nagaraju; Tyagi, Ujjawal; Kaldhi, Dhananjaya; Velayutham, Ravichandiran; Singh, Virender; Gupta, Sreya; Malakar, Chandi C.Tetrazoles are distinguished by a five-membered, doubly unsaturated ring which consists of four nitrogen and one carbon atom with a molecular formula CN4H2, which have a wide range of medicinal activity and potential role in biosciences. Interest in tetrazole chemistry in recent decades has been increasing rapidly because of diverse biological and pharmaceutical applications, mostly due to the diversity of this N-heterocyclic moiety in medicinal chemistry. This moiety offers a more appreciative pharmacokinetic profile and plays the role of metabolically stable substitute for carboxylic acid functional group as well as exhibits a broad range of biological effects such as analgesic, antibacterial, anticancer, anti-inflammatory, antidiabetic, antifungal, antitubercular and antihyperlipidemic activities. This chapter highlights the unique features of the potential possible role of tetrazole derivatives and summarizes biological and pharmacological activities. � 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.Item An Overview on Biological Activities of Oxazole, Isoxazoles and 1,2,4-Oxadiazoles Derivatives(Springer Nature, 2022-03-07T00:00:00) Gujjarappa, Raghuram; Sravani, Sattu; Kabi, Arup K.; Garg, Aakriti; Vodnala, Nagaraju; Tyagi, Ujjawal; Kaldhi, Dhananjaya; Singh, Virender; Gupta, Sreya; Malakar, Chandi C.Heterocyclic compounds containing the oxazole, isoxazole and oxadiazoles rings have received significant consideration as they perform like a link between life sciences and chemical sciences. In the past few years, the efficacy of these heterocyclic nuclei as synthetic intermediates for the development of novel chemical entities in medicinal and pharmaceutical chemistry has enhanced worldwide. Moreover, the importance of N-heterocycles from a medicinal point of view is due to their readily binding ability with biological systems such as various enzymes and receptors via numerous non-covalent interactions. Globally, similar research of finding Oxazole-based derivatives as potent medicinal drug candidates is an active topic which includes; oxazoles, isoxazoles, oxadiazoles, benzoxazoles, oxazolines, oxazolidinones, etc., in the study. Prominently, plenty of oxazole-based molecular scaffolds as active pharmacophores have been used against various diseases, which has shown their importance for the development as potential pharmaceutical agents. This chapter thoroughly highlights the current developments and researches involving; oxazole, isoxazole and oxadiazole-based compounds as clinical candidates, including anticancer, antibacterial, antiviral, antifungal, anti-inflammatory and antitubercular, antidiabetic as well as other biological activities. � 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.Item An Overview on Biological Activities of 1,2,3-Triazole Derivatives(Springer Nature, 2022-03-07T00:00:00) Kabi, Arup K.; Sravani, Sattu; Gujjarappa, Raghuram; Garg, Aakriti; Vodnala, Nagaraju; Tyagi, Ujjawal; Kaldhi, Dhananjaya; Singh, Virender; Gupta, Sreya; Malakar, Chandi C.Among the nitrogen-embedded heterocycles, 1,2,3-triazoles derivatives are widely explored and earned considerable attraction in pharmaceutical industry and academics. 1,2,3-Triazoles have attracted significant consideration during the last few years due to widespread implementation in synthetic organic chemistry, drug discovery process, supramolecular chemistry, chemical biology, polymer chemistry, fluorescent imaging as well as materials chemistry. Even though absent in nature, these N-heterocycles have a wide spectrum of medicinal applications against several malignant cells, microorganisms, viruses and their preclusive actions are resistant to various enzymes. Moreover, 1,2,3-triazoles-based scaffolds have been extensively immersed as a linker and a functional moiety, mainly owing to the fact that their processing simplicity, orthogonality development and attractive �Click� properties. This chapter highlights the recent developments on diversified biological efficiencies of 1,2,3-triazoles and their approach in the progress of novel bioactive as well as pharmacoactive entities in future. � 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.