Department Of Human Genetics And Molecular Medicine

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Author: search.filters.author.Kumar, Ajay

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    Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement
    (Springer Science and Business Media Deutschland GmbH, 2023-04-03T00:00:00) Kumar, Ajay; Sharma, Bunty; Sharma, Ujjawal; Parashar, Gaurav; Parashar, Nidarshana Chaturvedi; Rani, Isha; Ramniwas, Seema; Kaur, Satwinderjeet; Haque, Shafiul; Tuli, Hardeep Singh
    The Cucurbitaceae family produces a class of secondary metabolites known as cucurbitacins. The eight cucurbitacin subunits are cucurbitacin B, D, E, I, IIa, L glucoside, Q, and R with the most significant anticancer activity. They are reported to inhibit cell proliferation, invasion, and migration; induce apoptosis; and encourage cell cycle arrest, as some of their modes of action. The JAK-STAT3, Wnt, PI3K/Akt, and MAPK signaling pathways, which are essential for the survival and apoptosis of cancer cells, have also been shown to be suppressed by cucurbitacins. The goal of the current study is to summarize potential molecular targets that cucurbitacins could inhibit in order to suppress various malignant processes. The review is noteworthy since it presents all putative molecular targets for cucurbitacins in cancer on a single podium. � 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
    (MDPI, 2022-11-08T00:00:00) Singh Tuli, Hardeep; Kumar, Ajay; Ramniwas, Seema; Coudhary, Renuka; Aggarwal, Diwakar; Kumar, Manoj; Sharma, Ujjawal; Chaturvedi Parashar, Nidarshana; Haque, Shafiul; Sak, Katrin
    Despite the immense therapeutic advances in the field of health sciences, cancer is still to be found among the global leading causes of morbidity and mortality. Ethnomedicinally, natural bioactive compounds isolated from various plant sources have been used for the treatment of several cancer types and have gained notable attention. Ferulic acid, a natural compound derived from various seeds, nuts, leaves, and fruits, exhibits a variety of pharmacological effects in cancer, including its proapoptotic, cell-cycle-arresting, anti-metastatic, and anti-inflammatory activities. This review study presents a thorough overview of the molecular targets and cellular signaling pathways modulated by ferulic acid in diverse malignancies, showing high potential for this phenolic acid to be developed as a candidate agent for novel anticancer therapeutics. In addition, current investigations to develop promising synergistic formulations are also discussed. � 2022 by the authors.