Theses And Dissertation

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Subject: search.filters.subject.Eucalyptus tereticornis

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    In vitro and In silico study of Essential oil Components from Eucalyptus tereticornis as Antibacterial agents
    (Central University of Punjab, 2018) Sharma, Anupama; Jaitak,Vikas
    Many essential oils are known for their antimicrobial activity and the main target is bacterial cell membrane which is important for bacterial viability and hence the study was done to find the target and effective binding of the components of the Eucalyptus tereticornis essential oil and comparison with the standard drug used for in vitro and in silico studies, A/S combination. In vitro and In silico studies has shown the potential of Eucalyptus tereticornis essential oil in modulating antibacterial resistance and its potential as an antibacterial agent at a conc. of 10µl that was comparable with the standard and also at 50 µl, the zone of inhibition was found to be equivalent to that of standard combinational drug of A/S (10:10) mcg. The In silico studies further confirms its potential to combat antibacterial resistance as the docking results has shown the effective binding of the components of essential oil than the standard in the order ?-Terpinyl acetate (-2.754)> 8-epi-gama-eudermol> beta-eudesmol> L-alpha-Terpineol against PBP3 in comparison with the standard (-0.766). Docking simulation also suggests the effective binding of essential oil components with the beta lactamases as (-2.348) for Salbactam in comparison with (-3.671) Cis-p-mentha-1(7),8-dien-2-ol and also ADME/T studies has shown their ability to partition the bacterial cell membrane with logPo/w for the components for Aromadendrene (5.176), beta-myrcene (4.592). Along with 100% oral 6 absorption and the absorption through gut blood barrier QPPCaco found to be more than 500 for every component of the essential oil, and brain blood barrier that was found to be in range of 0.095 for alpha-terpinylacetate and 1.047 for Aromadendrene.
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    Phytotoxic potential of essential oil from leaves of eucalyptus tereticornis against rice (orza sativa) and its weeds, echinochloa grus-galli and cyperus rotundus
    (Central University of Punjab, 2016) Vishwakarma, Gajendra Singh; Mittal, Sunil
    The present study was undertaken to explore the phytotoxic potential of essential oil from Eucalyptus tereticornis against two major weeds of rice viz. Echinochloa crus-galli and Cyperus rotundus. The effect of essential oil was studied on growth (percent germination, root length and shoot length development) physiological parameters (chlorophyll content and percent respiration) and biochemical changes in macromolecule content (protein and carbohydrate) under controlled conditions in the laboratory. Studies revealed that Eucalyptus tereticornis essential oil (in different concentrations ranging from 25 to 250 µg/ml) adversely affected the growth and physiology of all the test plants. However the effect was more predominant in weeds compare to the rice seedlings. When the seeds of test plants were exposed to 100 and 250 µg/ml oil concentration, seed germination and seedling development of test weeds were highly affected as compare to the rice. C. rotundus was found to be the most sensitive weed among test plants. In chlorophyll content, the percent reduction at 250 µg/ml of essential oil was 60% 80% and 99% in O. sativa, E. crus-galli and C. rotundus, respectively. Similarly, reduction in respiratory activity on exposure to 250 µg/ml of essential oil was 20% 40% and 99% in O. sativa, E. crus-galli and C. rotundus, respectively. The effect of essential oil on macromolecules, i.e. carbohydrates and proteins also followed the similar trend. The percent reduction in protein content was approximately 40%, 60% and 80% and percent reduction in carbohydrate content was 25% 60% and 90% in O. sativa, E. crus-galli and C. rotundus, respectively on exposure to 100 µg/ml of essential oil. The present study concludes that essential oil of E. tereticornis shows the toxicity selectively towards the E. crus-galli and C. rotundus compare to O.sativa.