School Of Basic And Applied Sciences

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Author: search.filters.author.Jaitak, VikasSubject: search.filters.subject.Sodium azide

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    Invitro anti-mutagenic potential of potentilla fulgens: A western himalayan plant
    (Informatics Publishing Limited, 2014) Monga, P.; Kaur, R.; Jaitak, Vikas
    Invitro anti-mutagenic potential of different extracts/fractions of Potentilla fulgens has been made by an Ames histidine reversion assay using TA98 and TA100 tester strains of Salmonella typhimurium against the direct-acting mutagens, 4-Nitro-O-phenylenediamine (NPD) and Sodium azide. P. fulgens has been used in traditional system of medicine as anti-hyperglycemic, hypoglycemic, anti-hyperlipidemic, anti-oxidant, anti-inflammatory and anti-ulcerogenic agent. Results indicated that n-butanol and water fractions showed strong inhibition activity against the mutagens (NPD, Sodium azide) in both co-incubation as well as pre-incubation treatments in TA98 and TA100 tester strains. ? 2017, Informatics Publishing Limited. All rights reserved.
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    In-vitro anti-mutagenic activity of Asparagus racemosus: An ayurvedic medicinal plant
    (Academic Journals Inc., 2013) Singh, Ramit; Kaur, Rajbir; Arora, Saroj; Jaitak, Vikas
    Asparagus racemosus is a plant traditionaly used in epilepsy, as a brain tonic, cardiac disorders, hypertension, habitual abortions, weakness of the uterus, excessive bleeding during menstruation. The current study evaluated the antimutagenic pottential of methanolic (RME) and aqueous methanolic extract (RAE) extracted from A. racemosus. Ames assay was used to acess the antimutagenic potential of RME and RAE (2.5x103, 1.0x103, 0.5x103, 0.25x103, 0.10x103 and 0.01x103 ?g 0.1 mL plate-1) that was added with mutagenic activation of TA98 and TA100 strain of Salmonella typhimurium. A. racemosus extract RME and RAE have been found to have effective in the inhibition of mutation induced by NPD and sodium azide. Among the two extracts, RAE showed maximum inhibition of 49.2% followed by RME having inhibition of 40.63% in Co-incubation mode. Current study indicated that A. racemosus can be used as a new source of anti-mutagenic. ? 2013 Academic Journals Inc.