School Of Basic And Applied Sciences

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    Amino acid functionalized zinc oxide nanostructures for cytotoxicity effect and hemolytic behavior: Theoretical and experimental studies
    (Elsevier Ltd, 2017) Singh, Satvinder; Singh, Baljinder; Sharma, Prateek; Mittal, Anu; Kumar, Sanjeev; Saini, G.S.S.; Tripathi, S.K.; Singh, Gurinder; Kaura, Aman
    Blending of theoretical and experimental approach, provide an important strategy in designing the nanostructure at a microscopic level and helps in predicting the response of synthesized material towards inhibition of the growth of breast cancer cell. In this work, ab initio calculations using super cell approach are performed for three different amino acids (AAs)-Histidine (His), Arginine (Arg) and Aspartic acid (Asp) coated Zinc oxide (ZnO) nanostructures to explain the growth mechanism of nanoparticles (NPs) of different shapes. Based on the first principles calculations, we reveal that ZnO-AA (Arg and Asp) NPs results in rod like and ZnO-His NPs lead to tablet like configuration. Similar morphologies are fabricated using AAs through synthetic route. The effect of concentration ratio of reactants and pH has been studied. As synthesized samples, are characterized by using Transmission Electron Microscopy (TEM), X-ray diffraction (XRD), Fourier Transform Infrared (FTIR) and UV?Vis spectroscopy techniques. Based on the results, a plausible mechanism of formation of nanostructures has been proposed. The nanostructures with rod like morphology are found to be biocompatible with normal red blood cells and show cytotoxic effect as evaluated from hemolysis and cytotoxicity assays on breast (MCF-7, T47D, MDA-MB-231) & prostate cancer (PC-3) cell lines. ? 2017 Elsevier Ltd
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    Gelatin: A comprehensive report covering its indispensable aspects
    (Nova Science Publishers, Inc., 2016) Ul Rehman, W.; Majeed, A.; Mehra, R.; Bhushan, S.; Rani, P.; Saini, K.C.; Bast, Felix
    Gelatin is a collagen derived product, obtained by incomplete hydrolysis of collagen procured from skin, bones and connective tissues of animals and exhibits flavourlessness, colourlessness and translucency. It is commonly utilised as a gelling agent and also as additive in food, drugs, cosmetics, paints, matches, photographic films and foam stabilizer. The overall amino acid composition and proportion of gelatin varies according to the source of raw material, however glycine, proline and hyrdoxyproline constitute almost 60% of the total amino acid residues while cysteine is absent. Besides being used in food industries, gelatin based composites and blends are used in pharmacy for manufacturing biocompatible gelatin scraps, tissue engineering films and controlled drug delivery systems. This chapter focuses on the physio-chemical properties of gelatin, its extraction, composites and blends. ? 2016 Nova Science Publishers, Inc.