School Of Basic And Applied Sciences

Permanent URI for this communityhttps://kr.cup.edu.in/handle/32116/17

Browse

Filters

20183

Settings

Subject: search.filters.subject.Lung cancer

Search Results

Now showing 1 - 4 of 4
  • No Thumbnail Available
    Item
    Rapid Arc-SBRT: Non-Invasive Immune Adjuvant for Advanced Stage Non-Small Cell Lung Carcinoma
    (Bentham Science Publishers, 2021-03-23T00:00:00) Chairmadurai, Arun; Jain, Sandeep K.; Jain, Aklank; Prakash, Hridayesh
    In conjunction with radio-chemotherapy, pulmonary resection is recommended for early-stage non-small-cell lung carcinoma but not for advanced-stage NSCLC patients having high-grade metastatic lesions. In these cases, the rapid Arc-Stereotactic body radiotherapy (Ra-SBRT) technique offers a therapeutic advantage by delivering focal irradiation to metastatic lung lesions and reduces the bystander toxicity to normal tissues. We have previously demonstrated that Ra-SBRT ablates metastatic lesions and induces tumor immune rejection of metastatic tumors by promoting in situ programming of M2 TAM towards M1-TAM and infiltration of Siglec-8+ Eosinophils. Most interestingly, Ra SBRT has very low abscopal impact and spares normal tissues, which are the significant limitations with conventional radiotherapy. In view of this and the immune adjuvant potential of Ra SBRT, it promotes normalization of aberrant vasculature and inhibits the metastatic potential of NSCLC lesions. In view of this, we here propose that Ra-SBRT indeed represents an immunogenic approach for the effective management of advanced-stage NSCLC. � 2022 Bentham Science Publishers.
  • No Thumbnail Available
    Item
    Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review.
    (Bentham Science, 2018) Kumar, Manvendra; Singla, Ramit; Jandriyal, Jyoti; Jaitak, Vikas
    Background: The prevalence of lung cancer is 14% among the newly diagnosed cancer cases worldwide. Currently, the number of drugs that are in clinical practice is having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect. Objective: Extensive exploration of Coumarin derivatives as a potent inhibitor of variety of proteins including EGFR, tyrosine kinase, ERK1/2, PI3K, HSP 90, Bax, STAT proteins, NF-κB and telomerase which have been associated with lung cancer. Method: The recent literature was surveyed utilizing the online resources and databases including scifinder, pubchem, EMBL, scopus and google scholar. Results: Upon analyzing the structure-activity relationship, it was found that N-aryl carboxamide, phenyl substitution at the C-3 position and 1,2,3- triazolyl, trihydroxystilbene, amino substitution at the C-4 position of the coumarin nucleus were the most effective in targeting lung cancer. Conclusion: This review is a collaborative and extensive compilation of synthetic strategies, mechanism of action, and the structure-activity relationship thereof for the management of lung carcinoma.
  • No Thumbnail Available
    Item
    Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review
    (NLM (Medline), 2018) Kumar M.; Singla R.; Dandriyal J.; Jaitak V.
    BACKGROUND: The prevalence of lung cancer is 14% among the newly diagnosed cancer cases worldwide. Currently, the number of drugs that are in clinical practice is having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect. OBJECTIVE: Extensive exploration of Coumarin derivatives as a potent inhibitor of variety of proteins including EGFR, tyrosine kinase, ERK1/2, PI3K, HSP 90, Bax, STAT proteins, NF-?B and telomerase which have been associated with lung cancer. METHOD: The recent literature was surveyed utilizing the online resources and databases including scifinder, pubchem, EMBL, scopus and google scholar. RESULTS: Upon analyzing the structure-activity relationship, it was found that N-aryl carboxamide, phenyl substitution at the C-3 position and 1,2,3- triazolyl, trihydroxystilbene, amino substitution at the C-4 position of the coumarin nucleus were the most effective in targeting lung cancer. CONCLUSION: This review is a collaborative and extensive compilation of synthetic strategies, mechanism of action, and the structure-activity relationship thereof for the management of lung carcinoma. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
  • Thumbnail Image
    Item
    Expression Study of Long non-coding RNA SCAL1 and GAS6-AS1 in Lung cancer Cell line A549 Compared to IMR-90
    (Central University of Punjab, 2018) Pp, Arifa; Jain, Aklank
    Lung cancer is the fatal type of cancer owing to maximum number death worldwide. Despite the advances in clinical and experimental setup lung cancer still is the deadliest type of cancer wherein survival rate is as low as 15% five-yearly. The reason being the lack of proper candidate molecule for prognosis and diagnosis prior to invasion and metastasis. But usually, cancers are detected at later stages. The past cancer studies and investigations and investigations about tumorigenesis mechanism mostly focused on protein-coding gene considering them as principal regulators of cancer and diseases. But evidence from numerous high throughput genomic platform indicates that 98% of the eukaryotic genome is transcribed to non-coding RNA. The non-coding RNAs are significant in the regulation of many major biological processes that impact vi development, differentiation, and metabolism through different pathways. Non-coding RNA also plays a major role in cancer development and progression by influencing different cellular processes like proliferation, cell cycle progression, cell growth, and apoptosis. They also influence post-transcriptional gene regulation through controlling process like transport, splicing, transcriptional gene silencing, epigenetic gene expression, cell structure integrity etc. So we can assure that the long non-coding RNA and its altered expression play an important role in cancer etiology. In this project, we studied the expression of SCAL1 and GAS6-AS1 using qRT-PCR. The expression analysis shows that the long non-coding RNA is up-regulated (approximate 5-folds, P=0.000464) and GAS6-AS1 is down-regulated (approximate 4-folds, P=0.00378) in lung cancer cell line compared to control cell line. The melt curve analysis shows only one sharp peak for both SCAL1 and GAS6-AS1 and thereby indicates that there is only one specific primer binding and the primer dimer is not formed.