Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review.
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Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Bentham Science
Abstract
Background: The prevalence of lung cancer is 14% among the newly diagnosed cancer cases worldwide. Currently, the number of drugs that are in clinical practice is having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect.
Objective: Extensive exploration of Coumarin derivatives as a potent inhibitor of variety of proteins including EGFR, tyrosine kinase, ERK1/2, PI3K, HSP 90, Bax, STAT proteins, NF-κB and telomerase which have been associated with lung cancer.
Method: The recent literature was surveyed utilizing the online resources and databases including scifinder, pubchem, EMBL, scopus and google scholar.
Results: Upon analyzing the structure-activity relationship, it was found that N-aryl carboxamide, phenyl substitution at the C-3 position and 1,2,3- triazolyl, trihydroxystilbene, amino substitution at the C-4 position of the coumarin nucleus were the most effective in targeting lung cancer.
Conclusion: This review is a collaborative and extensive compilation of synthetic strategies, mechanism of action, and the structure-activity relationship thereof for the management of lung carcinoma.
Description
Keywords
Lung cancer, MDR, Coumarin, NSCLC, SCLC, Multidrug resistance.
Citation
Kumar, Manvendra., Singla, Ramit and Jandriyal, Jyoti (2018) Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review. Anti-Cancer Agents in Medicinal Chemistry. Vol. 18(7), PP> 964-984. 10.2174/1871520618666171229185926