Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review.

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dc.contributor.authorKumar, Manvendra
dc.contributor.authorSingla, Ramit
dc.contributor.authorJandriyal, Jyoti
dc.contributor.authorJaitak, Vikas
dc.date.accessioned2019-03-26T09:06:01Z
dc.date.accessioned2024-08-13T12:06:27Z
dc.date.available2019-03-26T09:06:01Z
dc.date.available2024-08-13T12:06:27Z
dc.date.issued2018
dc.description.abstractBackground: The prevalence of lung cancer is 14% among the newly diagnosed cancer cases worldwide. Currently, the number of drugs that are in clinical practice is having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect. Objective: Extensive exploration of Coumarin derivatives as a potent inhibitor of variety of proteins including EGFR, tyrosine kinase, ERK1/2, PI3K, HSP 90, Bax, STAT proteins, NF-κB and telomerase which have been associated with lung cancer. Method: The recent literature was surveyed utilizing the online resources and databases including scifinder, pubchem, EMBL, scopus and google scholar. Results: Upon analyzing the structure-activity relationship, it was found that N-aryl carboxamide, phenyl substitution at the C-3 position and 1,2,3- triazolyl, trihydroxystilbene, amino substitution at the C-4 position of the coumarin nucleus were the most effective in targeting lung cancer. Conclusion: This review is a collaborative and extensive compilation of synthetic strategies, mechanism of action, and the structure-activity relationship thereof for the management of lung carcinoma.en_US
dc.identifier.citationKumar, Manvendra., Singla, Ramit and Jandriyal, Jyoti (2018) Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review. Anti-Cancer Agents in Medicinal Chemistry. Vol. 18(7), PP> 964-984. 10.2174/1871520618666171229185926en_US
dc.identifier.doi10.2174/1871520618666171229185926
dc.identifier.issn1875-5995
dc.identifier.urihttp://10.2.3.109/handle/32116/2232
dc.identifier.urlhttp://www.eurekaselect.com/158734/article
dc.language.isoenen_US
dc.publisherBentham Scienceen_US
dc.subjectLung canceren_US
dc.subjectMDRen_US
dc.subjectCoumarinen_US
dc.subjectNSCLCen_US
dc.subjectSCLCen_US
dc.subjectMultidrug resistance.en_US
dc.titleCoumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review.en_US
dc.title.journalAnti-Cancer Agents in Medicinal Chemistryen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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