Biosensors for breast cancer diagnosis: A review of bioreceptors, biotransducers and signal amplification strategies
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Ltd
Abstract
Breast cancer is highly prevalent in females and accounts for second highest number of deaths, worldwide. Cumbersome, expensive and time consuming detection techniques presently available for detection of breast cancer potentiates the need for development of novel, specific and ultrasensitive devices. Biosensors are the promising and selective detection devices which hold immense potential as point of care (POC) tools. Present review comprehensively scrutinizes various breast cancer biosensors developed so far and their technical evaluation with respect to efficiency and potency of selected bioreceptors and biotransducers. Use of glycoproteins, DNA biomarkers, micro-RNA, circulatory tumor cells (CTC) and some potential biomarkers are introduced briefly. The review also discusses various strategies used in signal amplification such as nanomaterials, redox mediators, p19 protein, duplex specific nucleases (DSN) and redox cycling. ? 2016 Elsevier B.V.
Description
Keywords
Activation Analysis, Biomarkers, Biosensors, Diagnosis, Nanostructured Materials, Nucleic Acids, Signal Processing, Breast Cancer, Breast Cancer Diagnosis, Duplex-Specific Nuclease, Redox Cycling, Redox Mediators, Selective Detection, Signal Amplifications, Technical Evaluation, Diseases, Aptamer, Autoantibody, Biological Marker, Bioreceptor, Cell Free Dna, Complementary Dna, Dna, Duplex Specific Nuclease, Glycoprotein, Microrna, Nanomaterial, Nuclease, Protein P19, Quantum Dot, Receptor, Tumor
Citation
Mittal, S., Kaur, H., Gautam, N., & Mantha, A. K. (2017). Biosensors for breast cancer diagnosis: A review of bioreceptors, biotransducers and signal amplification strategies. Biosensors and Bioelectronics, 88, 217-231. doi: 10.1016/j.bios.2016.08.028