Role of immune system in tumor progression and carcinogenesis
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Date
2018
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Publisher
Wiley-Liss Inc.
Abstract
Tumor micro-environment has potential to customize the behavior of the immune cell according to their need. In immune-eliminating phase, immune cells eliminate transformed cells but after tumor establishment innate and adaptive immune cells synergistically provide shelter as well as fulfill their requirement that helps in progression. In between eliminating and establishment phase, equilibrium and escaping phase regulate the immune cells response. During immune-escaping, (1) the antigenic response generated is either inadequate, or focused entirely on tolerance, and (2) immune response generated is specific and effective, but the tumor skips immune recognition. In this review, we are discussing the critical role of immune cells and their cytokines before and after the establishment of tumor which might play a critical role during immunotherapy. ? 2018 Wiley Periodicals, Inc.
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Keywords
Chemokine, Cytokine, Tumor antigen, Adaptive immunity carcinogenesis, Dendritic cell, Human, Immune system, Immunity, Immunocompetent cell, Immunosurveillance, Immunotherapy, Innate immunity, Macrophage, Malignant neoplasm, Natural killer cell, Natural killer T cell, Neutrophil, Non human, Priority journal, T lymphocyte, Tumor growth, Tumor microenvironment
Citation
Upadhyay, S., Sharma, N., Gupta, K. B., & Dhiman, M. (2018). Role of immune system in tumor progression and carcinogenesis. Journal of Cellular Biochemistry, 119(7), 5028-5042. doi: 10.1002/jcb.26663