To study the effects of insulin and metformin on pc-3 cell line
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Date
2016
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Central University of Punjab
Abstract
Dietary habits, genetic factors, hormonal factors and environmental factors are the independent risk factors for prostate cancer as well as diabetes. Androgen is the primary growth factor for the prostate cancer initiation and progression, however, non androgen peptide growth factor like insulin and insulin growth factor also involved in the prostate cancer as well as diabetes. Insulin and insulin growth factor are peptide that regulates metabolism, growth, cellular proliferation and apoptosis. The anti-diabetic drug metformin is rapidly emerging as a potential anti-cancer agent that improves insulin homeostasis and decreased growth and cellular proliferation of the prostate cancer cell line. Thus it is necessary to understand the growth promoting role of insulin on prostate cancer cell line and the possible influences of metformin on the proliferation of prostate cancer cell line in the presence and absence of insulin has been studied.
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Keywords
Insulin, Metformin and Prostate Cancer, Metformin and Prostate Cancer (PC-3) cell line
Citation
Singh, Pushpendra (2016) To study the effects of insulin and metformin on pc-3 cell line