The emerging role of long non-coding RNA in gallbladder cancer pathogenesis
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier B.V.
Abstract
Gallbladder cancer (GBC) is the most common and aggressive form of biliary tract carcinoma with an alarmingly low 5-year survival rate. Despite its high mortality rate, the underlying mechanisms of GBC pathogenesis are not completely understood. Recently, from a growing volume of literature, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression and appear to play vital roles in many human cancers. To date, a number of lncRNAs have been implicated in GBC, but their potential roles in GBC have not been systematically examined. Thus, in this review, we critically discuss the emerging roles of lncRNAs in GBC, and the pathways involved. Specifically, we note that some lncRNAs show greater expression in T1 and T2 tumor stages compared to T3 and T4 tumor stages and that their dysregulation leads to alterations in cell cycle progression and can cause an increase in GBC cell proliferation or apoptosis. In addition, some lncRNAs control the epithelial-mesenchymal transition process, while others take part in the regulation of ERK/MAPK and Ras cancer-associated signaling pathways. We also present their potential utility in diagnosis, prognosis, and/or treatment of GBC. The overall goal of this review is to stimulate interest in the role of lncRNAs in GBC, which may open new avenues in the determination of GBC pathogenesis and may lead to the development of new preventive and therapeutic strategies for GBC. ? 2016 Elsevier B.V. and Soci?t? Fran?aise de Biochimie et Biologie Mol?culaire (SFBBM)
Description
Keywords
Antisense Non Coding In The Ink4 Locus, Colon Cancer Associated Transcript 1, Hox Transcript Antisense Rna, Long Intergenic Non Coding Rna Itgb1, Long Non Coding Rna Low Expression In Tumor, Long Untranslated Rna, Long Untranslated Rna Kiaa0125, Maternally Expressed Gene 3, Metastasis Associated Lung Adenocarcinoma Transcript 1, Rna H19, Unclassified Drug, Long Untranslated Rna, Tumor Marker, Carcinogenesis, Gallbladder Cancer, Gene Function, Human, Molecular Pathology, Nonhuman, Review, Apoptos
Citation
Khandelwal, A., Malhotra, A., Jain, M., Vasquez, K. M., & Jain, A. (2017). The emerging role of long non-coding RNA in gallbladder cancer pathogenesis. Biochimie, 132, 152-160. doi: 10.1016/j.biochi.2016.11.007