The emerging role of long non-coding RNA in gallbladder cancer pathogenesis

Simple item page
dc.contributor.authorKhandelwal, Akanksha
dc.contributor.authorMalhotra, Akshay
dc.contributor.authorJain, Manju
dc.contributor.authorVasquez, Karen M.
dc.contributor.authorJain, Aklank
dc.contributor.authorKhandelwal, A.
dc.contributor.authorMalhotra, A.
dc.contributor.authorJain, M.
dc.contributor.authorVasquez, K.M.
dc.contributor.authorJain, A.
dc.date.accessioned2018-01-31T11:40:17Z
dc.date.accessioned2024-08-13T13:21:56Z
dc.date.available2018-01-31T11:40:17Z
dc.date.available2024-08-13T13:21:56Z
dc.date.issued2017
dc.description.abstractGallbladder cancer (GBC) is the most common and aggressive form of biliary tract carcinoma with an alarmingly low 5-year survival rate. Despite its high mortality rate, the underlying mechanisms of GBC pathogenesis are not completely understood. Recently, from a growing volume of literature, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression and appear to play vital roles in many human cancers. To date, a number of lncRNAs have been implicated in GBC, but their potential roles in GBC have not been systematically examined. Thus, in this review, we critically discuss the emerging roles of lncRNAs in GBC, and the pathways involved. Specifically, we note that some lncRNAs show greater expression in T1 and T2 tumor stages compared to T3 and T4 tumor stages and that their dysregulation leads to alterations in cell cycle progression and can cause an increase in GBC cell proliferation or apoptosis. In addition, some lncRNAs control the epithelial-mesenchymal transition process, while others take part in the regulation of ERK/MAPK and Ras cancer-associated signaling pathways. We also present their potential utility in diagnosis, prognosis, and/or treatment of GBC. The overall goal of this review is to stimulate interest in the role of lncRNAs in GBC, which may open new avenues in the determination of GBC pathogenesis and may lead to the development of new preventive and therapeutic strategies for GBC. ? 2016 Elsevier B.V. and Soci?t? Fran?aise de Biochimie et Biologie Mol?culaire (SFBBM)en_US
dc.identifier.citationKhandelwal, A., Malhotra, A., Jain, M., Vasquez, K. M., & Jain, A. (2017). The emerging role of long non-coding RNA in gallbladder cancer pathogenesis. Biochimie, 132, 152-160. doi: 10.1016/j.biochi.2016.11.007en_US
dc.identifier.doi10.1016/j.biochi.2016.11.007
dc.identifier.issn3009084
dc.identifier.urihttp://10.2.3.109/handle/32116/560
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0300908416303741?via%3Dihub
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.subjectAntisense Non Coding In The Ink4 Locusen_US
dc.subjectColon Cancer Associated Transcript 1en_US
dc.subjectHox Transcript Antisense Rnaen_US
dc.subjectLong Intergenic Non Coding Rna Itgb1en_US
dc.subjectLong Non Coding Rna Low Expression In Tumoren_US
dc.subjectLong Untranslated Rnaen_US
dc.subjectLong Untranslated Rna Kiaa0125en_US
dc.subjectMaternally Expressed Gene 3en_US
dc.subjectMetastasis Associated Lung Adenocarcinoma Transcript 1en_US
dc.subjectRna H19en_US
dc.subjectUnclassified Drugen_US
dc.subjectLong Untranslated Rnaen_US
dc.subjectTumor Markeren_US
dc.subjectCarcinogenesisen_US
dc.subjectGallbladder Canceren_US
dc.subjectGene Functionen_US
dc.subjectHumanen_US
dc.subjectMolecular Pathologyen_US
dc.subjectNonhumanen_US
dc.subjectReviewen_US
dc.subjectApoptosen_US
dc.titleThe emerging role of long non-coding RNA in gallbladder cancer pathogenesisen_US
dc.title.journalBiochimie
dc.typeReviewen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
MS_GBC.pdf
Size:
1.32 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description:
Download

Collections

Zoology - Research Publications