Browsing by Title
Now showing items 3219-3238 of 3506
-
Tah1, A Key Component of R2TP Complex that Regulates Assembly of snoRNP, is Involved in De Novo Generation and Maintenance of Yeast Prion [URE3]
(Academic Press, 2021-03-31)The cellular chaperone machinery plays key role in the de novo formation and propagation of yeast prions (infectious protein). Though the role of Hsp70s in the prion maintenance is well studied, how Hsp90 chaperone machinery ... -
Tah1, A Key Component of R2TP Complex that Regulates Assembly of snoRNP, is Involved in De Novo Generation and Maintenance of Yeast Prion [URE3]
(Academic Press, 2021-03-31)The cellular chaperone machinery plays key role in the de novo formation and propagation of yeast prions (infectious protein). Though the role of Hsp70s in the prion maintenance is well studied, how Hsp90 chaperone machinery ... -
Tailoring of the structural, morphological, electrochemical, and dielectric properties of solid polymer electrolyte
(Institute for Ionics, 2019)A solid polymer electrolyte composed of poly(ethylene oxide) and sodium hexafluorophosphate has been synthesized with a varying fraction of succinonitrile via solution cast technique. Impedance spectroscopy, transference ... -
Targeted mutagenesis of two homologous ATP-binding cassette subfamily G (ABCG) genes in tomato confers resistance to parasitic weed Phelipanche aegyptiaca
(Springer Japan, 2021-03-11)Phelipanche aegyptiaca and Orobanche spp. are obligate plant root-parasitic weeds that cause extensive damage in agricultural crop plants. Their germination requires exposure to strigolactones (SLs) exuded by the host plant ... -
Targeting Breast Cancer-Derived Stem Cells by Dietary Phytochemicals: A Strategy for Cancer Prevention and Treatment
(MDPI, 2022-06-10)Breast cancer is heterogeneous disease with variable prognosis and therapeutic response. Approximately, 70% of diagnosed breast cancer represents the luminal A subtype. This subpopulation has a fair prognosis with a lower ... -
Targeting calcium homeostasis and impaired inter-organelle crosstalk as a potential therapeutic approach in Parkinson's disease
(Elsevier Inc., 2023-08-02)Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to motor symptoms such as tremors, rigidity, and ... -
Targeting cancer stem cells pathways for the effective treatment of cancer
(Bentham Science Publishers, 2020)Resistance to chemotherapy and relapse are major hurdles for the effective treatment of cancer. Major reason for this is a small sub population of cancer stem cells (CSCs) and its microenvironment. CSCs are critical driving ... -
Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease
(Elsevier B.V., 2023-06-29)Alzheimer's disease (AD) is a neurodegenerative disease that manifests its pathology through synaptic damage, mitochondrial abnormalities, microRNA deregulation, hormonal imbalance, increased astrocytes & microglia, ... -
Targeting Mitochondria as a Novel Disease-Modifying Therapeutic Strategy in Cancer
(Springer Nature, 2022-01-31)Mitochondria are important for the metabolism of energy, regulation of apoptosis and cell signaling. Overproduction of reactive oxidation species (ROS) in mitochondria is one of the indications of cancer cells; moreover, ... -
Targeting Mitochondria as a Novel Disease-Modifying Therapeutic Strategy in Cancer
(Springer Singapore, 2022-09-28)Mitochondria are essential for the metabolism of energy, regulation of apoptosis, and cell signaling. Overproduction of reactive oxidation species (ROS) in mitochondria is one of the indications of cancer cells. Moreover, ... -
Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer
(Elsevier Masson s.r.l., 2023-02-09)The importance of mitochondria is not only limited to energy generation but also in several physical and chemical processes critical for cell survival. Mitochondria play an essential role in cellular apoptosis, calcium ion ... -
Targeting mitochondria in the regulation of neurodegenerative diseases: A comprehensive review
(John Wiley and Sons Inc, 2022-07-20)Mitochondria are one of the essential cellular organelles. Apart from being considered as the powerhouse of the cell, mitochondria have been widely known to regulate redox reaction, inflammation, cell survival, cell death, ... -
Targeting mitochondrial bioenergetics as a promising therapeutic strategy in metabolic and neurodegenerative diseases
(Elsevier B.V., 2022-05-11)Mitochondria are the organelles that generate energy for the cells and act as biosynthetic and bioenergetic factories, vital for normal cell functioning and human health. Mitochondrial bioenergetics is considered an important ... -
Targeting Redox Homeostasis of Tumor Cells by Therapeutic Compounds in Cancer: An Indian Perspective
(Springer Singapore, 2022-09-28)Cancer is one of the significant causes of morbidity and mortality in the world. The role of oxidative stress in tumor progression and metastasis has been under focus since the last two decades, suggesting the importance ... -
Targeting the Epidermal Growth Factor Receptor with Molecular Degraders: State-of-the-Art and Future Opportunities
(American Chemical Society, 2023-02-22)Epidermal growth factor receptor (EGFR) is an oncogenic drug target and plays a critical role in several cellular functions including cancer cell growth, survival, proliferation, differentiation, and motility. Several ... -
Taxonomic reappraisal of Monostromataceae (Ulvophyceae: Chlorophyta) based on multi-locus phylogeny
(Taylor and Francis Ltd., 2015)Monostromataceae have been considered a morphologically discrete group of green algae having thalli made up of a single layer of cells; the family is ubiquitous in intertidal zones of marine and estuarine habitats across ... -
Taxonomical establishment and compositional studies of a new cordyceps (ascomycetes) species from the northwest himalayas (India)
(Begell House Inc., 2016)During a frequent survey in the northwest Indian Himalayan region, a new species-Cordyceps macleodganensis-was encountered. This species is described on the basis of its macromorphological features, microscopic details, ... -
TcI isolates of Trypanosoma cruzi exploit the antioxidant network for enhanced intracellular survival in macrophages and virulence in mice
(American Society for Microbiology, 2016)Trypanosoma cruzi species is categorized into six discrete typing units (TcI to TcVI) of which TcI is most abundantly noted in the sylvatic transmission cycle and considered the major cause of human disease. In our study, ... -
Teachers Attitude towards Use of ICT in Technical and Non-Technical Institutes
(MCSER Publishing, 2014)In this study the group of teachers working in technical colleges and non-technical colleges both are selected to find out their attitudes towards use of ICT as their instructional resources in classrooms. As it is the ... -
Teaching efectiveness of Secondary school Teachers in Relation to Demographic factors
(Social reserach Foundation, 2018)