School of Health Sciences

L-Methionine prevents β-cell damage by modulating the expression of Arx, MafA and regulation of FOXO1 in type 1 diabetic rats

Navik U., Rawat K., Tikoo K. (Elsevier, 2022)

L-Methionine (L-Met) is an essential sulphur-containing amino acid having a vital role in various key cellular processes. Here we investigated the effect of L-Met on streptozotocin-induced β-cell damage model of diabetes ...

Recent Advances in Molecular Pathways and Therapeutic Implications Targeting Mitochondrial Dysfunction for Alzheimer’s Disease

Dhapola R., Sarma P., Medhi B., Prakash A., Reddy D.H.K. (Springer, 2022)

Alzheimer’s disease (AD) is a neurodegenerative disorder which leads to mental deterioration due to aberrant accretion of misfolded proteins in the brain. According to mitochondrial cascade hypothesis, mitochondrial ...

Formulation and evaluation of SGLT2 inhibitory effect of a polyherbal mixture inspired from Ayurvedic system of medicine

Kumar A., Negi A.S., Chauhan A., Semwal R., Kumar R., Semwal R.B., Singh R., Joshi T., Chandra S., Joshi S.K., Semwal D.K. (National Taiwan University, 2022)

Background and aim: The ingredients viz., Artemisia roxburghiana, Cissampelos pareira, Stephania glabra, Drimia indica, Roylea cinerea, Tinospora sinensis and Curcuma longa of the present formulation are used to treat ...

Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish

Sharma M., Gupta P.K., Gupta P., Garabadu D. (Elsevier, 2022)

Ethnopharmacological relevance: Bacopa monnieri L. (Scrophulariaceae) is commonly known as Brahmi and traditionally used as a neuroprotective herbal medicine. Recently, Bacopa monnieri exhibited significant therapeutic ...

L-Methionine supplementation attenuates high-fat fructose diet-induced non-alcoholic steatohepatitis by modulating lipid metabolism, fibrosis, and inflammation in rats

Navik U., Sheth V.G., Sharma N., Tikoo K. (Royal Society of Chemistry, 2022)

Recently, the protective effects of a methionine-rich diet on hepatic oxidative stress and fibrosis have been suggested but not adequately studied. We, therefore, hypothesized that l-methionine supplementation would ...

Galangin, as a Potential Anticancer Agent

Singh D., Saini A., Singh R., Agrawal R. (Springer, 2022)

Cancer is a major global health issue and one of the main causes of mortality worldwide. In recent years, cancer mortality and morbidity rates have risen dramatically due to variety of factors. Despite therapeutic alternatives, ...

Neuroprotective role of apocynin against pentylenetetrazole kindling epilepsy and associated comorbidities in mice by suppression of ROS/RNS

Jaiswal G., Kumar P. (Elsevier, 2022)

Epilepsy is a neurological disease that transpires due to the unusual synchronized neuronal discharge within the central nervous system, which drives repetitious unprovoked seizures. Nicotinamide adenine dinucleotide ...

Biomedical applications of polysaccharide nanoparticles for chronic inflammatory disorders: Focus on rheumatoid arthritis, diabetes and organ fibrosis

Allawadhi P., Singh V., Govindaraj K., Khurana I., Sarode L.P., Navik U., Banothu A.K., Weiskirchen R., Bharani K.K., Khurana A. (Elsevier, 2022)

Polysaccharides are biopolymers distinguished by their complex secondary structures executing various roles in microorganisms, plants, and animals. They are made up of long monomers of similar type or as a combination of ...

Bacopa monnieri attenuates glutamate-induced nociception and brain mitochondrial toxicity in Zebrafish

Sharma M., Gupta P., Garabadu D. (Springer, 2022)

Bacopa monnieri L. (BM; Family: Scrophulariaceae), commonly known as Brahmi, is traditionally used as a nootropic agent. BM also exhibits significant analgesic activity in experimental models of pain. However, the effect ...

Gene therapy: Comprehensive overview and therapeutic applications

Sayed N., Allawadhi P., Khurana A., Singh V., Navik U., Pasumarthi S.K., Khurana I., Banothu A.K., Weiskirchen R., Bharani K.K. (Elsevier, 2022)

Gene therapy is the product of man's quest to eliminate diseases. Gene therapy has three facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where the desired gene in the form of plasmids and viral ...

Design, synthesis and anticancer activity of 2-arylimidazo[1,2-a]pyridinyl-3-amines

Yadav U.P., Ansari A.J., Arora S., Joshi G., Singh T., Kaur H., Dogra N., Kumar R., Kumar S., Sawant D.M., Singh S. (Academic Press Inc., 2022)

A series of imido-heterocycle compounds were designed, synthesized, characterized, and evaluated for the anticancer potential using breast (MCF-7 and MDA-MB-231), pancreatic (PANC-1), and colon (HCT-116 and HT-29) cancer ...

Functional implications of the CpG island methylation in the pathogenesis of celiac disease

Ghosh S., Khetarpal P., Senapati S. (Springer, 2022)

Investigation of gene-environment cross talk through epigenetic modifications led to better understanding of the number of complex diseases. Clinical heterogeneity and differential treatment response often contributed by ...

Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

Bhatti J.S., Sehrawat A., Mishra J., Sidhu I.S., Navik U., Khullar N., Kumar S., Bhatti G.K., Reddy P.H. (Elsevier, 2022)

Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide. It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia induced reactive oxygen species (ROS) production ...

Components of IGF-axis in growth disorders: a systematic review and patent landscape report

Singh A., Pajni K., Panigrahi I., Dhoat N., Senapati S., Khetarpal P. (Springer, 2022)

Purpose: In this review, epi/genetic mutations of IGF-axis components associated with growth disorders have been summarized alongwith assessment of relevant diagnostic and therapeutic technology through patent literature. ...

Burden of Type 2 Diabetes and Associated Cardiometabolic Traits and Their Heritability Estimates in Endogamous Ethnic Groups of India: Findings From the INDIGENIUS Consortium

Venkatesan V., Lopez-Alvarenga J.C., Arya R., Ramu D., Koshy T., Ravichandran U., Ponnala A.R., Sharma S.K., Lodha S., Sharma K.K., Shaik M.V., Resendez R.G., Venugopal P., Parthasarathy R., Saju N., Ezeilo J.A., Bejar C., Wander G.S., Ralhan S., Singh J.R., Mehra N.K., Vadlamudi R.R., Almeida M., Mummidi S., Natesan C., Blangero J., Medicherla K.M., Thanikachalam S., Panchatcharam T.S., Kandregula D.K., Gupta R., Sanghera D.K., Duggirala R., Paul S.F.D. (Frontiers Media S.A., 2022)

To assess the burden of type 2 diabetes (T2D) and its genetic profile in endogamous populations of India given the paucity of data, we aimed to determine the prevalence of T2D and estimate its heritability using family-based ...