RSS 1.0School of Health Sciences
Departments within this School
Recent Submissions
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Emerging role of non-coding RNA in health and disease
(Springer, 2021)Human diseases have always been a significant turf of concern since the origin of mankind. It is cardinal to know the cause, treatment, and cure for every disease condition. With the advent and advancement in technology, ... -
Epilepsy and Migraine Shared Genetic and Molecular Mechanisms: Focus on Therapeutic Strategies
(Springer, 2021)Epilepsy and migraine are both episodic disorders and share clinical as well as pathophysiological mechanisms. The prevalence of epilepsy in migraine patients is generally higher than normal as compared to general population ... -
Synthesis, in vitro, and docking analysis of c-3 substituted coumarin analogues as anticancer agents
(Bentham Science, 2021)Background: Breast cancer (BC) is a leading cause of cancer-related deaths in women next to skin cancer. Estrogen receptors (ERs) play an important role in the progression of BC. Current anticancer agents have several ... -
Microglia Specific Drug Targeting Using Natural Products for the Regulation of Redox Imbalance in Neurodegeneration
(Frontiers Media, 2021)Microglia, a type of innate immune cell of the brain, regulates neurogenesis, immunological surveillance, redox imbalance, cognitive and behavioral changes under normal and pathological conditions like Alzheimer�s, ... -
Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management
(Elsevier, 2021)Doxorubicin (Dox) is a secondary metabolite of the mutated strain of Streptomyces peucetius var. Caesius and belongs to the anthracyclines family. The anti-cancer activity of Dox is mainly exerted through the DNA intercalation ... -
�The pharmacological profile of SGLT2 inhibitors: Focus on mechanistic aspects and pharmacogenomics�
(Elsevier, 2021)Diabetes, characterized by high glucose levels, has been listed to be one of the world's major causes of death. Around 1.6 million deaths are attributed to this disease each year. Persistent hyperglycemic conditions in ... -
CYP19 gene rs2414096 variant and differential genetic risk of polycystic ovary syndrome: a systematic review and meta-analysis
(Taylor and Francis Ltd., 2021)Background: Previously, many studies investigated the association between CYP19 rs2414096(G > A) and susceptibility to develop PCOS. However, results had been inconsistent. Therefore, our systematic review and meta-analysis ... -
Mitochondria-Targeted Small Peptide, SS31 Ameliorates Diabetes Induced Mitochondrial Dynamics in Male TallyHO/JngJ Mice
(Springer, 2021)The escalating burden of type 2 diabetes (T2D) and its related complications has become a major public health challenge worldwide. Substantial evidence indicates that T2D is one of the culprits for the high prevalence of ... -
Design, synthesis, biological evaluation of 3,5-diaryl-4,5-dihydro-1H-pyrazole carbaldehydes as non-purine xanthine oxidase inhibitors: Tracing the anticancer mechanism via xanthine oxidase inhibition
(Academic Press Inc., 2021)Xanthine oxidase (XO) has been primarily targeted for the development of anti-hyperuriciemic /anti-gout agents as it catalyzes the conversion of xanthine and hypoxanthine into uric acid. XO overexpression in various cancer ... -
Studies on Genomic Alterations in HER2-Positive Breast Cancer–Focus on Design, Synthesis & Evaluation of Anilinoquinazoline Analogues as Potential HER2 inhibitors
(Central University of Punjab, 2019)Human epidermal growth factor receptor 2-positive (HER2-positive) breast cancer is an aggressive breast cancer subtype characterized by HER2 overexpression/amplification. Genomic alterations of HER2 and others have been ... -
Pharmacogenetics of Cyclophosphamide and Doxorubicin in Breast Cancer & Synthesis and Biological Evaluation of New Imidazole Based Putative Anticancer Agents
(Central University of Punjab, 2019)Breast cancer is the second most prevalent cancer in women worldwide. It is treated by various strategies, including surgery, radiation therapy, hormonal therapy, targeted therapy and chemotherapy. Chemotherapeutic drugs ... -
Epidemiological factors, genetic and inflammatory markers in the development of Breast Cancer in Malwa region of Punjab
(Central University of Punjab, 2019)Breast cancer is one of the most common malignancy among women and also the leading cause of death worldwide. Malwa region of Punjab is reported to have the highest number of cancer cases in comparison with the other two ... -
Transcriptional Regulation of Pro-metastatic Protein Formin Binding Protein17 (FBP17) in Breast Cancer
(Central University of Punjab, 2018)Breast cancer is a diverse disease with multiple subtypes. Among the different molecular subtypes, triple negative breast cancers (TNBC) harbor frequent mutation in tumor suppressor p53. Recently it was shown that p53 ... -
Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies
(Taylor and Francis Ltd., 2020)Coronaviruses are contagious pathogens primarily responsible for respiratory and intestinal infections. Research efforts to develop antiviral agents against coronavirus demonstrated the main protease (Mpro) protein may ... -
Mechanisms of Anti-Tumor Activity of Withania somnifera (Ashwagandha)
(Routledge, 2020)Increasing herbal formulations have been used to treat several diseases including cancer. W. somnifera (Ashwagandha) is one such plant the extracts of which have been tested against a number of ailments including cancer, ... -
Establishing molecular signatures of stroke focusing on omic approaches: a narrative review
(Taylor and Francis Ltd, 2020)Stroke or �brain attack� is considered to be the major cause of mortality and morbidity worldwide after myocardial infraction. Inspite of the years of research and clinical practice, the pathogenesis of stroke still remains ... -
miRNA dysregulation in ischaemic stroke: Focus on diagnosis, prognosis, therapeutic and protective biomarkers
(Blackwell Publishing Ltd, 2020)Stroke is one of the leading causes of death and disability in both developing and developed countries. Biomarkers for stroke and its outcome can greatly facilitate early detection and management of the disease. miRNAs ... -
Combinatorial Effect of DCA and Let-7a on Triple-Negative MDA-MB-231 Cells: A Metabolic Approach of Treatment
(SAGE Publications Inc., 2020)Dichloroacetate (DCA) is a metabolic modulator that inhibits pyruvate dehydrogenase activity and promotes the influx of pyruvate into the tricarboxylic acid cycle for complete oxidation of glucose. DCA stimulates oxidative ... -
Anti-cancer drug doxorubicin induced cardiotoxicity: Understanding the mechanisms involved in ros generation resulting in mitochondrial dysfunction
(Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma, 2020)Doxorubicin (DOX), despite being an effective anti-cancer drug has offsite targets that affect the vital organs such as heart, brain and kidney. DOX-induced cardiotoxicity is reported as a multi-factorial process that ... -
Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human
(Springer, 2020)At present, more than 200 countries and territories are directly affected by the coronavirus disease-19 (COVID-19) pandemic. Incidence and case fatality rate are significantly higher among elderly individuals (age > 60 ...
