RSS 1.0School of Health Sciences
Recent Submissions
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KIBRA Team Up with Partners to Promote Breast Cancer Metastasis
(Springer, 2019)Among women, breast cancer is the most frequently diagnosed cancer. Most of the breast cancers represent metastasis to distant organs at the time of diagnosis and accounts for the majority of deaths. Metastasis is characterized ... -
Serum homocysteine could be used as a predictive marker for chronic obstructive pulmonary disease: A meta-analysis
(Frontiers Media S.A., 2019)Background: Serum homocysteine (Hcy) level is inversely related with concentration of folic acid, which is an essential micronutrient for metabolism and energy homeostasis. Serum concentrations of Hcy have been reported ... -
Systematic review and meta-analysis to establish the association of common genetic variations in Vitamin D binding protein with chronic obstructive pulmonary disease
(Frontiers Media S.A., 2019)Background: Vitamin-D binding protein (DBP) also known as GC protein, is a major determinant for vitamin- D metabolism and transport. GC1F, GC1S, and GC2 are the three allelic variants (denoted as rs4588 and rs7041) of GC, ... -
Genomic alterations associated with HER2+ breast cancer risk and clinical outcome in response to trastuzumab
(Springer, 2019)Human epidermal growth factor receptor 2 positive (HER2+) breast cancer (BC) is an aggressive BC subtype characterized by HER2 overexpression/amplification. Genomic alterations of HER2 and others have been reported to be ... -
Systematic review and meta-analysis confirms significant contribution of surfactant protein D in chronic obstructive pulmonary disease
(Frontiers Media S.A., 2019)Background: Surfactant protein D (SFTPD) is a lung specific protein which performs several key regulatory processes to maintain overall lung function. Several infectious and immune mediated diseases have been shown to be ... -
Pd-Catalyzed Four-Component Sequential Reaction Delivers a Modular Fluorophore Platform for Cell Imaging
(American Chemical Society, 2019)A Pd-catalyzed cascade reaction of four versatile privileged synthons is described. The sequential reaction involves the formation of five new chemical bonds by concatenating three distinct chemical steps. One of the ... -
Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling
(Springer, 2019)Cancer, the leading causes of death worldwide, causes multiple metabolic and physiological alterations, leading to an unregulated proliferation of cells. The existing anticancer therapies are usually nonspecific with side ... -
Effect of TiO2 and Fe doped TiO2 nanoparticles on mitochondrial membrane potential in HBL-100 cells
(American Institute of Physics, 2019)Titanium dioxide (TiO2) nanoparticles (NPs) have made unbelievable progress in the field of nanotechnology and biomedical research. The proper toxicological assessment of TiO2 NPs and the reduction of its cytotoxicity need ... -
Computational investigation of binding mechanism of substituted pyrazinones targeting corticotropin releasing factor-1 receptor deliberated for anti-depressant drug design
(Taylor and Francis, 2019)In spite of various research investigations towards anti-depressant drug discovery program, no one drug has not yet launched last 20 years. Corticotropin-releasing factor-1 (CRF-1) is one of the most validated targets for ... -
A study of mechanistic mapping of novel SNPs to male breast cancer
(Humana Press Inc., 2019)Alterations in BRCA2, PALB2, CHEK2, and p53 genes have been identified for their association with male breast cancer in various studies. The incidence of male breast cancer in India is consistent with its global rate. The ... -
Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans
(Impact Journals, 2015)Lowering insulin-IGF-1-like signalling (IIS) activates FOXO transcription factors (TF) to extend life span across species. To study the dynamics of FOXO chromatin occupancy under this condition in C. elegans, we report the ... -
CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis
(Impact Journals, 2015)Signaling via epidermal growth factor receptor (EGFR) and Src kinase pathways promote triple-negative breast cancer (TNBC) cell invasion and tumor metastasis. Here, we address the role of Cdc42-interacting protein-4 (CIP4) ... -
Genetics of idiopathic generalized epilepsy: An overview
(Neurology Society of India, 2014)Idiopathic generalized epilepsy (IGE) is a common type of epilepsy. Strong support for a genetic role in IGE comes from twin and family studies. Several subtypes of IGE have been reported but families often have members ... -
Analysis of pro‐ and anti‐inflammatory cytokine gene variants and serum cytokine levels as prognostic markers in breast cancer
(Wiley, 2018)The aim of current study was to evaluate the genetic variation in all the genes encoding pro‐ and anti‐inflammatory cytokines in association with breast cancer development in patients from Malwa region of Punjab. The ... -
Synthetic versus Enzymatic Pictet-Spengler Reaction: An Overview.
(Bentham, 2018)Pictet-Spengler reactions is an irreplaceable part of cyclization reaction leading to the formation of indispensable heterocyclic moieties including imidazole, benzoxazole, pyrrole, indole and others having immense biological ... -
Dietary Patterns and Breast Cancer Risk: A Multi-Centre Case Control Study among North Indian Women
(mdpi, 2018)Evidence from India, a country with unique and distinct food intake patterns often characterized by lifelong adherence, may offer important insight into the role of diet in breast cancer etiology. We evaluated the association ... -
Awakening the "guardian of genome": reactivation of mutant p53.
(Springer, 2018)The role of tumor suppressor protein p53 is undeniable in the suppression of cancer upon oncogenic stress. It induces diverse conditions such as cell-cycle arrest, cell death, and senescence to protect the cell from ... -
Caulerpa taxifolia inhibits cell proliferation and induces oxidative stress in breast cancer cells
(Springer, 2018)Caulerpa taxifolia (M. Vahl) C. Agardh or killer alga is known to possess several bioactive secondary metabolites with unique structural modifications. We investigated anti-oxidant and anti-proliferative activity of C. ... -
Genetics of platelet traits in ischemic stroke:Focus on mean platelet volume and platelet count
(Taylor & Francis, 2018)Stroke is one of the leading cause of disability and death worldwide. Evidence suggests that variants of genes involved in different pathways modulate the susceptibility to stroke. Various treatments given to these ...
