School of Health Sciences
Departments within this School
Recent Submissions
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Bacillus Calmette-Gu�rin Vaccine Attenuates Haloperidol-Induced TD-like Behavioral and Neurochemical Alteration in Experimental Rats
(2023-11-20)Tardive dyskinesia (TD) is a hyperkinetic movement disorder that displays unusual involuntary movement along with orofacial dysfunction. It is predominantly associated with the long-term use of antipsychotic medications, ... -
Unlocking the therapeutic potential of natural stilbene: Exploring pterostilbene as a powerful ally against aging and cognitive decline
(Elsevier Ireland Ltd, 2023-11-17)The therapeutic potential of natural stilbenes, with a particular focus on pterostilbene (PTE), has emerged as a promising avenue of research targeting age-associated conditions encompassing cardiovascular diseases (CVD), ... -
Therapeutic targeting of angiopoietins in tumor angiogenesis and cancer development
(Elsevier B.V., 2023-10-21)The formation and progression of tumors in humans are linked to the abnormal development of new blood vessels known as neo-angiogenesis. Angiogenesis is a broad word that encompasses endothelial cell migration, proliferation, ... -
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA
(Taylor and Francis Ltd., 2023-11-16)Introduction: Recent neuroscience breakthroughs have shed light on the sophisticated relationship between calcium channelopathies and movement disorders, exposing a previously undiscovered tale focusing on the Ryanodine ... -
Nanotherapeutics for Parkinson's disease using metal nanocomposites
(CRC Press, 2023-10-19)[No abstract available] -
Impact of noscapine on halting the progression of pentylenetetrazole induced kindling epilepsy in mice
(John Wiley and Sons Inc, 2023-09-19)Epilepsy is caused by an excessive recurrent excitatory neuronal firing, characterized by motor, psychomotor, and sensory impairments. Current therapies fail to produce 100% outcomes because of the complexity of the disease, ... -
Apoptotic Cell Death in Cardiomyocytes Induced by Hypoxia from Cobalt Chloride Is Hastened by SGLT-1 Inhibition
(Mary Ann Liebert Inc., 2023-09-19)Introduction: Myocardial ischemia is responsible for the deaths of millions of people every year. Cardiac hypoxia reduces the efficiency with which the heart muscle pumps blood. When one or more of the coronary arteries ... -
Advancing Cancer Immunotherapy: The Potential of mRNA Vaccines As a Promising Therapeutic Approach
(John Wiley and Sons Inc, 2023-10-04)mRNA vaccines have long been recognized for their ability to induce robust immune responses. The discovery that mRNA vaccines may also contribute to antitumor immunity has made them a promising therapeutic approach against ... -
Understanding the Cross-Talk between the Ceramide Biosynthetic Pathway and Mitochondrial Function in Multiple Sclerosis and Demyelinating Disorders
(Wiley-Hindawi, 2023-10-12)Myelin is a spiral compilation of uniformly thick membranes around the axon in an alternating fashion, and it is formed by a complicated process known as myelination. Myelin sheaths are responsible for various physiological ... -
1,3-Oxazine as a Promising Scaffold for the Development of Biologically Active Lead Molecules
(John Wiley and Sons Inc, 2023-10-16)Heterocyclic compounds form an important part of wide range of biologically active molecules. The heteroatom provides them specificity for various receptors. 1,3-oxazine has been considered as a privileged scaffold in many ... -
Neurodegenerative diseases and brain delivery of therapeutics: Bridging the gap using dendrimers
(Editions de Sante, 2023-08-26)Neurodegenerative diseases (NDs) continue to burden human lives and economic conditions. They continue to challenge the healthcare system due to the associated physiological barriers. Traditional treatment approaches are ... -
Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer's disease
(Elsevier B.V., 2023-09-13)Synaptic mitochondria are crucial for maintaining synaptic activity due to their high energy requirements, substantial calcium (Ca2+) fluctuation, and neurotransmitter release at the synapse. To provide a continuous energy ... -
Endoplasmic reticulum stress in Alzheimer's disease: Molecular mechanisms and therapeutic prospects
(Elsevier Inc., 2023-07-29)Alzheimer's disease (AD) is a progressive neurodegenerative condition that leads to memory loss and cognitive impairment over time. It is characterized by protein misfolding as well as prolonged cellular stress, such as ... -
Unveiling the Anthelminthic Potential of Merremia vitifolia Stem through in Vitro and in Silico Approach
(John Wiley and Sons Inc, 2023-09-16)This study aimed to assess the anthelmintic activity of methanol extracts from Merremia vitifolia stems using a combination approach encompassing experimental, in vitro, and in silico evaluations. Despite the well-recognized ... -
Daidzein Attenuates Ovariectomy-Induced Cognitive Deficits by Improving Cortical Endothelial Function in Rats
(Springer Science and Business Media Deutschland GmbH, 2023-07-17)There have been reports of decreased vascular activity in memory-sensitive brain areas, which is thought to be a different approach to managing cognitive deficiencies in females with estrogen insufficiency. Daidzein, a ... -
Treatment of diabetic complications: do flavonoids holds the keys?
(Taylor and Francis Ltd., 2023-07-12)Diabetes mellitus (DM) is an endocrinological disorder in which blood sugar levels get elevated and if unmanaged, it leads to several critical complications. Existing therapies or drugs are not able to attain absolute ... -
Exploring the ameliorative potential of Bacopa monnieri in acetic acid induced ulcerative colitis in mice
(Taylor and Francis Ltd., 2023-07-10)The aim of the present study was to evaluate the role of Bacopa monnieri in acetic-acid-induced ulcerative colitis in mice. Acetic acid (3%v/v, in 0.9% saline) was infused intrarectally to induce ulceration in mice. ... -
In Silico Study of the Structural Disruption of 14?-demethylase Induced by the Binding of Terminalia chebula Constituents
(Bentham Science Publishers, 2023-07-11)Background: Since ancient times, medicinal plants have been in use in medicine and daily life. Objective: To develop new antifungal compounds with low toxicity and high efficacy followed by high bioavailability, the ... -
Cucurbita pepo seeds improve peripheral neuropathy in diabetic rats by modulating the inflammation and oxidative stress in rats
(Springer Science and Business Media Deutschland GmbH, 2023-07-03)Background: Cucurbita pepo (C. pepo) is cultivated and used traditionally as vegetable as well as medicine in different parts of the world. The aim of current study was to investigate the potential of C. pepo in attenuation ... -
Ephrin B/EphB in neuropathic pain: Role and molecular mechanisms
(John Wiley and Sons Inc, 2023-07-04)Ephrins are protein ligands that act through the tyrosine kinase receptor family, Eph receptors. The role of ephrin/Eph in the critical processes involved in the development of the nervous system, including axon guidance ...