Chemistry - Master Dissertation

Permanent URI for this collection

http://10.2.3.109/handle/32116/34

Browse

Browsing Chemistry - Master Dissertation by Title

Now showing 1 - 10 of 10
  • Thumbnail Image
    Item
    Green Synthesis of Imidazopyridines
    (Central University of Punjab, 2018) Mehar, Nikhil Das; Kumar, Rakesh
    A green synthesis of imidazopyridineusing environmentally friendly ionic liquids have been explored. The role of imidazolium based ionic liquids was evaluated. It was found that alkyl side chain of ionic liquid play an important role for product formation. The best optimized condition includes the use of ionic liquid [hmim]Br. Even the reaction was found to proceed under water. This is of significant importanceas solvent waste and their disposal is one of the major challenges faced by chemical industries.
  • Thumbnail Image
    Item
    Host-Guest Interaction of calix[4]arene derivatives with MetforminAC
    (Central University of Punjab, 2018) Gupta, Harshita; BabuJ. Nagendra
    Calix[4]arene was lower rim functionalized to furnish receptor 2-3 and 4-6, containing propyl and cyanomethoxy moieties, respectively. The receptors were characterized by FTIR, 1H and EI-MS. UV-visible studies were performed with receptor 2-6 cone (1'10-4M) upon addition of metformin (1'10-5 - 1'10-3M). Upon addition of metformin the UV-Visible absorption showed a hyperchromic shift.The 1:1 Host-Guest complexation studied by Benesi-Hildebrand equation showed a stability constant in the range 2'104 -10'104 M-1 .
  • Thumbnail Image
    Item
    Implication of Methods and Techniques of Relaxation for Investigating the Iron release mechanism of Transferrin
    (Central University of Punjab, 2018) Singh, Jitender; Kumar, Rajesh
    Transferrins (Tfs, serum transferring (sTf), ovotransferrin (oTf), lactotransferrin(Lf)) are bilobal iron binding glycoprotein's. In the absence of iron, the two lobs are in open conformation. Upon complex formation with iron and the protein is transformed to closed conformation and each lobs forms interdomains hydrogen bond and these are different from one transferrin to other. More over iron release from sTf and oTf take places in mildly acidic media while Lf releases iron in acidic conditions. This difference is likely due to proton assisted di-lysines triggers present in N-lobe of sTF and oTF but absent in Lf. This difference also reflected in kinetic and mechanism of iron release from TFs under mildly acidic pH conditions in the presence of physiological anions. This project discussing the implication of methods and techniques of relaxation for investigating the kinetics and mechanisms of iron release from Tfs' The comparison in kinetic and mechanistic steps of iron release from diferric-sTf, oTf and Lf showed that under mildly acidic conditions, the iron release from diferric-sTf and oTf occur in multiphasic manner while in diferric-sTf it occur it single phase
  • Thumbnail Image
    Item
    NiO QDs /ZnO nanorods composite structure for catalytic reduction of Cr6+
    (Central University of Punjab, 2018) Ahmed, Imtiaz; Haldar, K.K
    Infront of the emerging interest and talent to search for new materials, we have synthesized Nickel oxide (NiO) nanoparticles decorated Zinc oxide (ZnO) nanorods composite (NiO/ZnO) nanostructure. By the X-ray powder diffraction and high-resolution transmission electron microscopy (HRTEM) the NiO/ZnO heterostructure formation was confirmed. The fabricated environmental affable NiO/ZnO composite nanostructure under UV-lights shows a well-defined photoreduction characteristic of hexavalent Chromium (Cr) (VI) to tri-valent Chromium (Cr) (III). Photoluminescence (PL) spectroscopy, photocurrent study, and electrochemical impedance spectroscopy, proved that the superior photoreduction property is ascribed due to the decreased electron-hole recombination process. In addition to the photocatalytic activity rate of the NiO decorated ZnO nanorods was much higher than that of exposed ZnO nanorods dfv for the reduction of chromium (VI) and their rate of activity is found to be 0.306 min?1 . All results have demonstrates that in the development of highperformance photocatalyst the suitable surface engineering may open up new opportunities.
  • Thumbnail Image
    Item
    NMR Spectroscopy of Small Sized Proteins
    (Central University of Punjab, 2018) Sharma, Vishal; Kumar, Rajesh
    In this project, the NMR spectra of proteins is discussed and the one dimensional 1H NMR protein spectra of ferricytochrome and lysozome is collected to study the conformational changes in them by varying the pH values from neutral to alkaline. In this thesis it is focused on that why we are not able to study larger and complex protein molecules with NMR spectra, what are the advantages of NMR spectra in the study of proteins and why we need multidimensions in protein NMR.
  • Thumbnail Image
    Item
    One pot synthesis of Au embedded ZnO nanorods composite heterostructures with excellent photocatalytic properties
    (Central University of Punjab, 2018) Biswas, Rathindranath; Haldar, Krishna Kanta
    Here, we have designed a noble composite nanostructure by embedding Au nanoparticles into ZnO nanorods surface in one pot synthesis as a photocatalyst. The formation the composite nanostructure was confirmed by X-ray diffraction, Xray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) investigations. Microscopic studies suggest that spherical Au nanoparticles are nucleated on the ZnO nanorods surface. XPS shows shifting of peak positions towards higher binding energy indicating charge transfer from ZnO to Au in the composite nanostructures. This is unambiguously confirmed by the steady state spectroscopic studies. It is found that 95.7% of Methylene blue (MB) dye is degraded by the composite nanostructure after 140 min under UV light illumination, and the apparent rate constant is found to be 0.013 min-1 . This new class of Au nanoparticles embedded ZnO nanorods composite nanostructure opens up new possibilities in photocatalytic, solar energy conversion, photovoltaic, and other new emerging applications.
  • Thumbnail Image
    Item
    Polynuclear Aromatic Hydrocarbon (PAH) Inclusion in Lower Rim Substituted Calix[4]arene
    (Central University of Punjab, 2018) Ram, Mange; Babu, J. Nagendra
    Calix[4]arene was lower rim functionalized to furnish receptor 2-3 and 4-6, containing propyl and cynomethoxy moieties respectively. The receptors were characterized by FTIR, EI-MS, 1H and 13C NMR. UV-visible studies were performed with receptor 2-5 cone and 6th 1-3,aternate. (2x10-4) upon addition of Naphthalene, Anthracene and Pyrene. Upon addition of Naphthalene, Anthracene and Pyrene the UV-visible absorption showed hyperchromic shift. The one-to-one Host-Guest complexation studied by Benesi-Hildebrand equation showed stability constant in the range 2-10x104 M-1 .
  • Thumbnail Image
    Item
    Size And Shape Of Crowding Control The Secondary Structure Folding Of Acid- Denatured Cytochrome C
    (Central University of Punjab, 2018) Sharma, Manoj; Kumar, Rajesh
    Macromolecular crowding, Cytochrome c, Circular Dichroism, Molten Globule, Dextran 40, Dextran 70, Ficoll 70
  • Thumbnail Image
    Item
    Study on Multicomponent Coupling of Aldehyde, Alkyne and Amine
    (Central University of Punjab, 2018) Kumar, Rohtash; Kumar, Rakesh
    The coupling of aldehyde, an amine and an alkyne (known as A3 -coupling) is a versatile strategy for the synthesis of propargylamine which are important precursors for various biologically active molecules. Various transition metal catalysts of Cu, Ag, Au, Fe, Ni, Zn, Co along with a variety of solvents have been reported for this reaction. However, metal/solvent waste and their disposal is one of the major challenges faced by chemical industries. Moreover, trapping of traces of metal impurity in the final product could be harmful. In this work, we have explored various environmental friendly solvents such as ionic liquids and water for the multicomponent coupling of hydroxybenzaldehyde with amine and alkyne. When there is OH group at ortho position of benzaldehyde, the reaction can be carried out without the presence of metal-catalyst. We found that this reaction can proceed even under solvent-less condition without the need of any metal catalyst. For comparison purpose, the effect of various molecule solvents on the yield of reaction has also been explored.
  • Thumbnail Image
    Item
    Synthesis and characterization of copper and silver complexes stabilized by Dithiocarbazate
    (Central University of Punjab, 2018) Rout, Sambit Shashanka Sekhar; Dhayal, Rajendra Singh
    Metal complexes of Dithiocarbazoic acid, it's esters and their Schiff bases have been considered for the potential of anticancer, antibacterial, antifungal, antiamoebic and insecticidal activities. S-methyldithiocarbazate, S-benzyldithiocarbazate and it's Schiff bases were already reported. We synthesize copper(I)/silver(I) complexes using of dithiocarbazate and it's Schiff base. We also isolated heteroatomic (copper and silver) complexes stabilized by dithiocarbazate. All the complexes are characterised by SEM (Scanning Electron Microscope), EDS (Energy dispersive X-ray Spectroscopy), Elemental mapping and NMR (Nuclear Magnetic Resonance). Further, we synthesize hetero clusters by the use of copper and silver, which can be utilized for making of nanoparticles and nanomaterials in near future.