Theses And Dissertation
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Item Assessment of antioxidant potential of phytochemicals in human glioblastoma (U-87 MG) cells(Central University of Punjab, 2014) Kaur, Manpreet; Mantha, Anil K.Imbalance between production of reactive oxygen/nitrogen species (ROS/RNS) leads to oxidative stress and has been well documented for mitochondrial dysfunction, a prime cause towards pathogenesis of neurological diseases and cancer. Glioblastoma Multiforme (GBM) is a highly aggressive, invasive and primary brain tumor which shows resistance to chemotherapy and radiotherapy. Superoxide dismutase (SOD) is an antioxidant enzyme that scavenges the production of superoxide radicals and dismutases into H?O? which is further converted into H?O and O? by catalase (CAT) enzyme. Apurinic/Apyrimidinic endonuclease (APE1) is a central enzyme of base excision repair (BER) pathway with two important functions; DNA repair and redox regulation of transcription factors (TFs) responsible for cell survival. In this study, it was seen that oxidative stress induced by endogenously found oxidants H?O? and glucose oxidase (GO) enhanced the activities of both CuZn-SOD and MnSOD in U-87 MG cells. In addition, CuZn-SOD levels were found to be increased in H?O?-induced oxidative stress and MnSOD levels were found to be increased in both H?O? and GO- induced oxidative stress. Further, pretreatment with phytochemicals Curcumin and Quercetin modulated the activities and expression of both forms of SOD studied. The BER-pathway enzyme, APE1 level was found to be decreased in mitochondria of oxidative stress induced U-87 MG cells by H?O? and GO, and in contrast APE1 level was found to be increased in cytosol, which indicates that oxidative stress affects the expression level and sub-cellular localization of APE1. Taken together, these results indicate that in GBM it is more likely that activated SOD a key player of antioxidant system and APE1 a key player in BER-pathway might be facilitating cancer cells to survive in oxidative stress environment.Item Women explotation in contemporary south asia: Field experiences of child marriage in bathinda district(Central University of Punjab, 2014) Kaur, Manpreet; Kaushiki, NishthaWomen are exploited at every step of her life. Child Marriage and marital violence happens to be the first phase and is one of the ways in which women are exploited. The present research is an attempt to bring to the surface various underlying causes and effects of Child marriage in their life. It is also a humble attempt to recommend some measures to stop child marriages and sexual abuse of the child bride/ marital rape cases. For this purpose, case studies from Bathinda District of Punjab have been selected for the field study. The study tries to evaluate the extent to which women have utilised the legislative measures against these two activities, experiences of the victims and the socio-economic causes behind the problem. Thus, this study is of immense importance for women empowerment as it attempts to create awareness among the people on the issue.Item Orientalising the Postcolonial Nation-State: A Study of The Inheritance of Loss and Half a Life(Central University of Punjab, 2012) Kaur, Manpreet; Kaur, ZameerpalIn the postcolonial analysis, the term nation-state has been critiqued mainly because the postcolonial nation states experience multiple exclusions and unequal power distribution. This feeling of marginalisation and exclusion is voiced by many postcolonial writers who are concerned with the psychological effects of the political and economic-cultural structures of the postcolonial world. Both the novels selected for this study, disclose the effects of up-rootedness and displacement and ultimately the quest for a particular nation-state. Kiran Desai in her The Inheritance of Loss deals with the themes of cultural conflicts, migration, nostalgia, globalization, multiculturalism, political struggles and economic inequality. Likewise, V. S. Naipaul in his novel Half a Life traces the themes of alienation, migration, displacement, rootlessness, mockery and self-deception of the emigrants. Biju in The Inheritance of Loss and Willie Chandran in Half a Life expose the gamut of issues including the multiple exclusion and distribution faced by postcolonial nation-states, threats of migration, loss of identity, globalization, and economic disparity. The attempt was to analyse both the texts selected for the study to bring forth the underlining beliefs and ideologies. The focus was also on understanding the effects political movements and situations have on personal relations. Study of both the texts foregrounds the miserable conditions of the lives of subaltern people and their continuous struggle and hope of assimilation in the postcolonial nation-states.Item Socio-cultural concerns in ajmer singh aulakh's sat begane and gurdial singh night of the half moon(Central University of Punjab, 2012) Kaur, Manpreet; Singh, Amandeep SinghAjmer Singh Aulakh and Gurdial Singh are two prominent Punjabi writers who belong to the Malwa region of Punjab. Both the writers portray the everyday realities of marginalised people especially small or landless farmers. Commercialisation of agriculture under the Green Revolution has changed the socio-cultural environment of Punjab considerably, and these changes get reflected in vernacular literature also. In this study, comparative analysis of writings of these two writers has been done so as to analyse various socio-cultural concerns present in their texts. Both the writers belong to a relatively backward area of Punjab, and have focused on small farmers. These texts show complexities of rural agricultural life where land is both the main source of all livelihood and is also cause of many disputes. Due to its power to make or break the future of a family, hold over land becomes an issue of life and death. This over-reliance over land distorts the personal and familial life, in which women are the main sufferers. This socio-economic situation gets compounded with the addition of feelings of revenge, honour etc. which draw their strength from the cultural milieu. Sat Begane and Night of the Half Moon under study portray this complex reality of Punjabi farming community. The focus of this study is on the complex socio-cultural factors and economic transformation of the region that has deeply affected the human relationships and value system during this period.Item Theme of Revolt in the Selected Poems of Pash and Lal Singh Dil(Central University of Punjab, 2012) Kaur, Manpreet; Kumar RajinderThe central theme of Punjabi poets Pash (Avtar Singh Sandhu) and Lal Singh Dil is a revolt against an unjust social and economic system. This study is an attempt to trace this theme by undertaking a detailed study of Pash Sampooran Pash Kav by Pash and Naaglok by Lal Singh Dil. The prime object of this research project is to bring into focus the issues of protest and revolt surfacing in the different classes of society in Punjab of sixties and seventies, through a comparative study of the two anthologies. Both two poets Pash and Lal Singh Dil are product of the revolutionary and explicitly political phase of Punjabi poetry. Their work is concerned with social, political and economic issues, particularly critiquing inequality, injustice and exploitation of the poor and the marginalised. Pash's poetry is a revolt against the inhuman political and social system of the country. Challenging the political system of the country, Pash refuses to be a gentle citizen accepting the things as they are. Casteism is a more important issue in Lal Singh Dil's poetry. Reflecting the deplorable circumstances of his life and that of those around him suffering extreme of poverty, injustice and oppression, he emerged as a major voice of the Dalits. Lal Singh Dil was very conscious of his caste and class and took up his pen for his fellow victims. Pash, who received more recognition than Dil during his life time, on the other hand, came from a relatively privileged class and his concerns are different. This comparative study tries to trace the type of revolt in the poems of both these poets.