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Now showing items 1300-1319 of 3506
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Galangin, as a Potential Anticancer Agent
(Springer Science and Business Media Deutschland GmbH, 2022-04-07)Cancer is a major global health issue and one of the main causes of mortality worldwide. In recent years, cancer mortality and morbidity rates have risen dramatically due to variety of factors. Despite therapeutic alternatives, ... -
Galangin: A metabolite that suppresses anti-neoplastic activities through modulation of oncogenic targets
(SAGE Publications Inc., 2021-12-14)With the dramatic increase in cancer incidence all over the world in the last decades, studies on identifying novel efficient anti-cancer agents have been intensified. Historically, natural products have represented one ... -
Gametogenic and steroidogenic action of kisspeptin-10 in the Asian catfish, Clarias batrachus: Putative underlying mechanistic cascade
(Elsevier Inc., 2021-06-28)Unlike mammals, two kisspeptins genes encoding, kiss1 and kiss2 are detected in fishes with highly varied and contradictory difference in their reproductive activities. The present study was undertaken to examine the direct ... -
Ganoderic Acid A Targeting ?-Catenin in Wnt Signaling Pathway: In Silico and In Vitro Study
(Springer Berlin Heidelberg, 2018)Wnt signaling pathways are the group of signaling transduction controlling the embryonic development, cell proliferation, cell migration, cell fate specification, and body axis pattern. Nuclear accumulation of ?-catenin ... -
Ganoderic Acid A Targeting β-Catenin in Wnt Signaling Pathway: In Silico and In Vitro Study
(Springer, 2016)Wnt signaling pathways are the group of signaling transduction controlling the embryonic development, cell proliferation, cell migration, cell fate specification, and body axis pattern. Nuclear accumulation of β-catenin ... -
Ganoderic acid modulating TNF and its receptors: in silico and in vitro study
(Springer, 2017)Cancer is a multifactorial disease with a network of genes causing genetic alterations. The sophisticated techniques in molecular biology revealed different cancer pathway, but their mechanistic approach is still shrouded. ... -
Ganoderic acid targeting multiple receptors in cancer: in silico and in vitro study
(Springer Netherlands, 2016)Receptor tyrosine kinases (RTKs) are transmembrane high-affinity surface receptors responsible for cell migration, adhesion, apoptosis, metabolism, and cell proliferation activities in various cancers. Minute aberration ... -
Ganoderic acid targeting nuclear factor erythroid 2–related factor 2 in lung cancer
(Sage, 2017)Lung cancer causes huge mortality worldwide, and targeting new pathway may provide an alternative in modulating signaling in cancer. Nuclear factor erythroid 2–related factor 2 is the major regulator of endogenous and ... -
Ganoderic acid, lanostanoid triterpene: a key player in apoptosis
(Springer New York LLC, 2018)Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell ... -
Ganoderma lucidum targeting lung cancer signaling: A review
(SAGE Publications Ltd, 2017)Lung cancer causes huge mortality to population, and pharmaceutical companies require new drugs as an alternative either synthetic or natural targeting lung cancer. The conventional therapies cause side effects, and ... -
GANODERMA LUCIDUM, A POTENTIAL THERAPEUTIC MODULATOR IN CANCER SIGNALING: IN SILICO AND IN VITRO ANALYSIS
(Central University of Punjab, 2018) -
Gap Solitons in Fiber Bragg Gratings Having Polynomial Law of Nonlinear Refractive Index and Cubic�Quartic Dispersive Reflectivity by Lie Symmetry
(MDPI, 2023-04-24)The current paper recovers cubic�quartic optical solitons in fiber Bragg gratings having polynomial law of nonlinear refractive index structures. Lie symmetry analysis is carried out, starting with the basic analysis. Then, ... -
GARLIC THE WONDER ADJUVANT IN MEDICINAL FIELD
(2022-05-16)Plant derived compounds are drawing attention in curing and treating variety of ailment and diseases. This increase in popularity of natural products has renewed interest in garlic, which has been used by human for centuries. ... -
Gaussian field-based 3D-QSAR and molecular simulation studies to design potent pyrimidine-sulfonamide hybrids as selective BRAFV600E inhibitors
(Royal Society of Chemistry, 2022-10-21)The �RAS-RAF-MEK-ERK� pathway is an important signaling pathway in melanoma. BRAFV600E (70-90%) is the most common mutation in this pathway. BRAF inhibitors have four types of conformers: type I (?C-IN/DFG-IN), type II ... -
Gaussian field-based comparative 3D QSAR modelling for the identification of favourable pharmacophoric features of chromene derivatives as selective inhibitors of ALR2 over ALR1
(Springer, 2021-01-07)Aldehyde reductase (ALR1) and aldose reductase (ALR2) are both oxo-reductase enzymes of aldo-keto reductase (AKR) superfamily involved in several cellular processes. ALR1 plays an important role in colorectal cancer, lungs, ... -
Gelatin: A comprehensive report covering its indispensable aspects
(Nova Science Publishers, Inc., 2016)Gelatin is a collagen derived product, obtained by incomplete hydrolysis of collagen procured from skin, bones and connective tissues of animals and exhibits flavourlessness, colourlessness and translucency. It is commonly ... -
Geminin a multi task protein involved in cancer pathophysiology and developmental process: A review
(Elsevier B.V., 2016)DNA replicates in a timely manner with each cell division. Multiple proteins and factors are involved in the initiation of DNA replication including a dynamic interaction between Cdc10-dependent transcript (Cdt1) and Geminin ... -
Geminin as an Emerging Anticancer Drug Target
(Juniper Publishers, 2016)For normal cell division, one time replication origin firing is mandatory. The mutual interaction and levels of Cdt1 and geminin (GMNN) proteins are known to be involved in this regulatory mechanism. Imbalance between these ... -
Gender Discrimination: Bane for the Society.
(Review of Research, 2014)One of the most significant economic development of 21st Century was the entry of women into paid jobs.The growing participation of women in the job sector was a major trend in all most all the industrialised nations in ...