Browsing Zoology-Research Publications by Author "Sarkar, Bibekananda"
Now showing items 1-7 of 7
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APE1/Ref-1 as an emerging therapeutic target for various human diseases: Phytochemical modulation of its functions
Thakur, Shweta; Sarkar, Bibekananda; Cholia, Ravi P.; Gautam, Nandini; Dhiman, Monisha; Mantha, Anil K. (Nature Publishing Group, 2014)Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme involved in the base excision repair (BER) pathway, which repairs oxidative base damage caused by endogenous and exogenous agents. APE1 acts as a ... -
Biodegradable nanoparticulate co-delivery of flavonoid and doxorubicin: Mechanistic exploration and evaluation of anticancer effect in vitro and in vivo
Khan, Iliyas; Sarkar, Bibekananda; Joshi, Gaurav; Nakhate, Kartik T.; Ajazuddin; Mantha, Anil K.; Kumar, Raj; Kaul, Ankur; Chaturvedi, Shubhra; Mishra, Anil K.; Gupta, Umesh (Elsevier Ltd, 2021-07-30)The proposed study involves delivering drug/bioactive using a single nanoplatform based on poly lactic-co-glycolic acid (PLGA) for better efficacy, synergistic effect, and reduced toxicity. PLGA was conjugated to doxorubicin ... -
Curcumin revitalizes Amyloid beta (25–35)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2
Sarkar, Bibekananda; Dhiman, Monisha; Mittal, Sunil; Mantha, Anil K. (Springer, 2017)Amyloid beta (Aβ) peptide deposition is the primary cause of neurodegeneration in Alzheimer’s disease (AD) pathogenesis. Several reports point towards the role of pesticides in the AD pathogenesis, especially organophosphate ... -
Indian Herbs and their Therapeutic Potential against Alzheimer’s Disease and other Neurological Disorders
Kaur, Navrattan; Sarkar, Bibekananda; Gill, Iqbal; Kaur, Sukhchain; Mittal, Sunil; Dhiman, Monisha; Padala, Prasad R.; Perez-Polo, Regino; Mantha, Anil K. (Wiley, 2017)Many present-day diseases are caused by disruption of the delicate balance between the reactive oxygen/nitrogen species (ROS/RNS) produced by oxidants and their scavenging by the antioxidants in the body. Chief among them ... -
ORGANOPHOSPHATE PESTICIDES PESTER Aβ- INDUCED GENOTOXIC RESPONSES IN CULTURED NEURONAL CELLS: APE1/Ref-1 MEDIATED INTERVENTION
Sarkar, Bibekananda (Central University of Punjab, 2018)Amyloid beta ( ) peptide deposition is the primary cause of neurodegeneration in reasons deposition, but the actual cause is not apparent. Several reports point towards the role of pesticides in the AD pathogenesis, ... -
A short review on the implications of base excision repair pathway for neurons: Relevance to neurodegenerative diseases
Mantha, Anil K.; Sarkar, Bibekananda; Tell, Gianluca (Elsevier, 2014)Oxidative DNA damage results from the attack by reactive oxygen and nitrogen species (ROS/RNS) on human genome. This includes base modifications such as oxidized bases, abasic (AP) sites, and single-strand breaks (SSBs), ... -
Understanding human thiol dioxygenase enzymes: structure to function and biology to pathology
Sarkar, Bibekananda; Kulharia, Mahesh; Mantha, Anil K. (Wiley, 2017)Amino acid metabolism is a significant metabolic activity in humans, especially of sulphur-containing amino acids, methionine and cysteine (Cys). Cys is cytotoxic and neurotoxic in nature; hence, mammalian cells maintain ...