RSS 1.0School of Basic and Applied Sciences
Departments within this School
Recent Submissions
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Understanding the principles of protein-protein interactions: Designing novel means for virtual proteomics
(Central University of Punjab, 2020)Proteins are the basic functional units in the cellular world of life. They are nano- machines programmed to associate with other biomolecules in order to enact an array of molecular functions in response to biological ... -
Evaluation of amyloid beta (aβ)-induced Mitochondrial dysfunction: Neuroprotective role of Apurinic/apyrimidinic endonuclease (ape1) Via its interaction with cysteamine Dioxygenase (ado)
(Central University of Punjab, 2020)Oxidative stress and damage to mitochondrial DNA during the aging process can impair mitochondrial energy metabolism and ion homeostasis in neurons, ultimately leading to neurodegeneration. Themain pathway for repairing ... -
Synthesis and Biological Evaluation of Inhibitors of Topoisomerases and Histone Deacetylase for In Vitro Anticancer Activity
(Central University of Punjab, 2019)Topoisomerases (Topos) and histone deacetylases (HDACs) are validated oncotherapeutic targets due to their involvement in most of the cellular events such as initiation, proliferation, and survival of cancer cells. Widespread ... -
STRUCTURAL AND ELECTROCHEMICAL PROPERTIES OF INTERCALATED AND DISPERSED TYPE POLYMER NANOCOMPOSITE FILMS
(Central University of Punjab, 2019)The renewable and green source of energy now becomes the burning topic for worldwide research among the scientists. The demand for such energy resources is increasing day by day and it becomes the lifeblood of modern ... -
Studies on adaptive environmental responses in Himalayan Rhododendron arboreum
(Central University of Punjab, 2019)Temperate plants acclimatize to survive freezing temperatures, which are otherwise prerequisite in the initiation/transition of a developmental phase. The dominance of Rhododendron arboreum under a highly fluctuating ... -
DNA barcode-based identification and comparative anti-cancer effects of different species of brown seaweed Sargassum C. Agardh of Indian coasts
(Central University of Punjab, 2018)Sargassum C. Agardh is a ubiquitous, multicellular brown seaweed that represents the most species-rich genus of the brown algal order Fucales, with more than 500 species reported worldwide. The present study aimed to ... -
Design, Synthesis and Evaluation of Indole Based Compounds as Putative Anticancer Agents
(Central University of Punjab, 2018)In the course of efforts to develop new chemotherapeutic agent for targeting breast cancer, indole-benzimidazole, indole-xanthendione, indole-chromene carbonitrile and indole-dihydropyridine derivatives were computationally ... -
GANODERMA LUCIDUM, A POTENTIAL THERAPEUTIC MODULATOR IN CANCER SIGNALING: IN SILICO AND IN VITRO ANALYSIS
(Central University of Punjab, 2018) -
ANALYSIS OF MICRORNA SIGNATURES AS BIOMARKER TO INVESTIGATE INTERLINK BETWEEN TYPE 2 DIABETES AND BREAST CANCER
(Central University of Punjab, 2018)Type 2 diabetes and breast cancer are two heterogeneous, multifactorial, chronic health problems involving several overlapping risk factors. Studies have suggested that type 2 diabetes is associated with 10-20% excessive ... -
ORGANOPHOSPHATE PESTICIDES PESTER Aβ- INDUCED GENOTOXIC RESPONSES IN CULTURED NEURONAL CELLS: APE1/Ref-1 MEDIATED INTERVENTION
(Central University of Punjab, 2018)Amyloid beta ( ) peptide deposition is the primary cause of neurodegeneration in reasons deposition, but the actual cause is not apparent. Several reports point towards the role of pesticides in the AD pathogenesis, ... -
A BIOCHEMICAL STUDY TO EVALUATE THE ROLE OF APURINIC/APYRIMIDINIC ENDONUCLEASE 1 (APE1) IN LUNG CANCER PROGRESSION
(Central University of Punjab, 2018)Globally, lung cancer has the highest incidence and mortality rate. Environmental factors such as chlorpyrifos (CP) and monocrotophos (MCP), widely used organophosphate pesticides (OPPs), and are reported to be involved ... -
OXIDATIVE STRESS INDUCED CELL PROLIFERATION AND DNA REPAIR MECHANISMS IN GLIOBLASTOMA CELLS: ROLE OF ENPP2 AND APE1
(Central University of Punjab, 2018)Glioblastoma Multiforme (GBM) is a grade IV, most frequent, and invasive devastating brain tumor with poor prognosis, even with the advancement of multimodal therapies, patients have survival period of less than 15 months. ... -
SYNTHESIS AND ANTICANCER EVALUATION OF NOVEL HETEROCYCLICS DERIVED FROM IMIDAZOLE AND QUINOLINE SCAFFOLDS
(Central University of Punjab, 2018) -
Screening of natural compounds for receptor tyrosine kinase inhibitors: in silico and in vitro investigation in cancer cell lines
(Central University of Punjab, 2016) -
DNA Barcoding, Phylogeny and Phylogeography of Green Sea Weed Ulva from Indian Subcontinent
(Central University of Punjab, 2019) -
In silico identification of natural anticancer product and their efficacy in breast cancer cells and cancer stem like cells
(Central University of Punjab, 2020)Breast cancer is the most commonly diagnosed lethal cancer in women worldwide. Notch signaling pathway is directly linked to breast cancer recurrence and aggressiveness. Natural remedies are becoming a prime choice to ... -
Design, Synthesis and Evaluation of Donepezil-Rasagiline Based Compounds as Multipotent Inhibitors for the Treatment of Alzheimer’s Disease
(Central University of Punjab, 2019)Alzheimer’s disease (AD) is multifactorial in nature and different enzymes including MAO, AChE, and amyloid beta are implicated in its pathogenesis. The pathomechanism of AD is complex in nature and single target drugs ... -
DNA barcoding and phylogeny based comparative evaluation of anti-cancer properties of Caulerpa (J V Lamouroux) spp. from Indian coasts
(Central University of Punjab, 2019)A total of 15 Caulerpa samples were collected from Indian coasts and identified based on morphological and molecular data inferred from ITS, 18S, tufA and rbcL. Seven different species viz. C. scalpelliformis, C. racemosa, ... -
Transcriptomic investigations of gene networks in response to arsenic accumulation in Brassica juncea (L.) Czern & Coss
(Central University of Punjab, 2019)Arsenic (As), a widespread toxic metalloid is class I carcinogen known to cause adverse health effects in human. In the present study, As accumulation potential and differential gene expression in B. juncea is investigated. ... -
Spectroscopic analysis of Muga silk nanoparticles synthesized by microwave method
(Wiley-Blackwell Publishing Ltd, 2020)Muga silk nanoparticles (MSNP) were synthesized using a microwave-assisted radiolysis method. The effect of microwave on the Muga protein secondary structures was analyzed. The evolution of the secondary structure from ...
