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Screening of multi-targeted natural compounds for receptor tyrosine kinases inhibitors and biological evaluation on cancer cell lines, in silico and in vitro
(Humana Press Inc., 2015)
Receptors for growth factors encompass within the superfamily of receptor tyrosine kinases and are known to regulate numerous biological processes including cellular growth, proliferation, metabolism, survival, cell ...
In silico molecular docking study of natural compounds on wild and mutated epidermal growth factor receptor
(Birkhauser Boston, 2014)
The role played by overexpression of tyrosine kinase epidermal growth factor receptor (EGFR), the transmembrane receptor central to numerous cellular processes comprising cell migration, adhesion, apoptosis, and cell ...
INFLUENCE OF INSULIN AND METFORMIN ON PROSTATE CANCER
(Nova Science Publishers, 2017)
Dietary habit and hormonal factor play a significant role in prostate cancer deregulation in addition to genetic and environmental factor. Nonandrogenic growth factor like insulin and insulin growth factor are influences ...
Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: Novel treatment strategies for cancer
(Humana Press Inc., 2014)
Insulin and insulin-like growth factor (IGF) signaling system, commonly known for fine-tuning numerous biological processes, has lately made its mark as a much sought-after therapeutic targets for diabetes and cancer. These ...
Screening and biological evaluation of myricetin as a multiple target inhibitor insulin, epidermal growth factor, and androgen receptor; In silico and in vitro
(Springer New York LLC, 2015)
Myricetin is a naturally omnipresent benzo-?-pyrone flavonoids derivative; has potent anticancer activity. Receptor tyrosine kinases family provides the decisive role in cancer initiation and progression. These receptors ...
Natural Compounds Targeting Transforming Growth Factor-β: In Silico and In Vitro Study
(ejBio, 2016)
Inhibition of the tumor-promoting effects of transforming growth factor beta receptor (TGFβR) in carcinogenesis provides a better therapeutic intervention. Various natural compounds, inhibitors of TGFβR have been used for ...
High-throughput virtual screening, identification and in vitro biological evaluation of novel inhibitors of signal transducer and activator of transcription 3
(Birkhauser Boston, 2015)
Signal transducer and activator of transcription (STAT) family, encompassing protein molecules that function as a second messenger and transcription factor, are famously known to regulate a multitude of cellular processes ...
IMPACT OF PERSONALIZED MEDICINE IN CANCER
(Nova Science Publishers, 2017)
Personalized medicine aims to customize therapeutic care based on a
person's unique genetic profile. Physicians have tailored care based on
individual's health history and the environment. However, the decoding
of the ...
Multitargeted molecular docking study of plant-derived natural products on phosphoinositide-3 kinase pathway components
(Springer, 2014)
Phosphoinositide-3 kinase (PI3K) signaling pathway comprises of a cornucopia of protein molecules capable of regulating numerous cellular events, including cell survival, cell cycle regulation, angiogenesis, and apoptosis. ...
In Silico and In Vitro Studies Evidenced Anticancer Natural Compounds, a Targeting Chemokine Receptor
(iMedPub, 2016)
Chemokines are a family of small chemotactic cytokines, which play a significant role in lymphocyte homing to secondary lymphoid organs in addition to tumor growth and metastasis. Thus, inhibition of chemokine receptor ...