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Ganoderic acid targeting nuclear factor erythroid 2–related factor 2 in lung cancer
(Sage, 2017)
Lung cancer causes huge mortality worldwide, and targeting new pathway may provide an alternative in modulating signaling in cancer. Nuclear factor erythroid 2–related factor 2 is the major regulator of endogenous and ...
Natural Compounds Targeting Transforming Growth Factor-β: In Silico and In Vitro Study
(ejBio, 2016)
Inhibition of the tumor-promoting effects of transforming growth factor beta receptor (TGFβR) in carcinogenesis provides a better therapeutic intervention. Various natural compounds, inhibitors of TGFβR have been used for ...
Ganoderic acid targeting multiple receptors in cancer: in silico and in vitro study
(Springer Netherlands, 2016)
Receptor tyrosine kinases (RTKs) are transmembrane high-affinity surface receptors responsible for cell migration, adhesion, apoptosis, metabolism, and cell proliferation activities in various cancers. Minute aberration ...
IMPACT OF PERSONALIZED MEDICINE IN CANCER
(Nova Science Publishers, 2017)
Personalized medicine aims to customize therapeutic care based on a
person's unique genetic profile. Physicians have tailored care based on
individual's health history and the environment. However, the decoding
of the ...
Multitargeted molecular docking study of plant-derived natural products on phosphoinositide-3 kinase pathway components
(Springer, 2014)
Phosphoinositide-3 kinase (PI3K) signaling pathway comprises of a cornucopia of protein molecules capable of regulating numerous cellular events, including cell survival, cell cycle regulation, angiogenesis, and apoptosis. ...
In Silico and In Vitro Studies Evidenced Anticancer Natural Compounds, a Targeting Chemokine Receptor
(iMedPub, 2016)
Chemokines are a family of small chemotactic cytokines, which play a significant role in lymphocyte homing to secondary lymphoid organs in addition to tumor growth and metastasis. Thus, inhibition of chemokine receptor ...
Antioxidant potential of ganoderic acid in Notch-1 protein in neuroblastoma
(Springer, 2018)
Neuroblastoma is a childhood tumor arising from developing a sympathetic nervous system and causes around 10% of pediatric tumors. Despite advancement in the use of sophisticated techniques in molecular biology, neuroblastoma ...
Vitex negundo and its medicinal value
(Springer, 2018)
Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Vitex negundo (VN), commonly known as “chaste tree”, is an ethnobotanically important ...
Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling
(Springer, 2019)
Cancer, the leading causes of death worldwide, causes multiple metabolic and physiological alterations, leading to an unregulated proliferation of cells. The existing anticancer therapies are usually nonspecific with side ...
Natural products as multidrug resistance modulators in cancer
(Elsevier, 2019)
Cancer is a prominent cause of death globally. Currently, many drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors acquiring resistance to chemotherapy ...