RSS 1.0Human Genetics and Molecular Medicine-Research Publications
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Pharmacogenetics of Cyclophosphamide and Doxorubicin in Breast Cancer & Synthesis and Biological Evaluation of New Imidazole Based Putative Anticancer Agents
(Central University of Punjab, 2019)Breast cancer is the second most prevalent cancer in women worldwide. It is treated by various strategies, including surgery, radiation therapy, hormonal therapy, targeted therapy and chemotherapy. Chemotherapeutic drugs ... -
Epidemiological factors, genetic and inflammatory markers in the development of Breast Cancer in Malwa region of Punjab
(Central University of Punjab, 2019)Breast cancer is one of the most common malignancy among women and also the leading cause of death worldwide. Malwa region of Punjab is reported to have the highest number of cancer cases in comparison with the other two ... -
Transcriptional Regulation of Pro-metastatic Protein Formin Binding Protein17 (FBP17) in Breast Cancer
(Central University of Punjab, 2018)Breast cancer is a diverse disease with multiple subtypes. Among the different molecular subtypes, triple negative breast cancers (TNBC) harbor frequent mutation in tumor suppressor p53. Recently it was shown that p53 ... -
Studies on Genomic Alterations in HER2-Positive Breast Cancer–Focus on Design, Synthesis & Evaluation of Anilinoquinazoline Analogues as Potential HER2 inhibitors
(Central University of Punjab, 2019)Human epidermal growth factor receptor 2-positive (HER2-positive) breast cancer is an aggressive breast cancer subtype characterized by HER2 overexpression/amplification. Genomic alterations of HER2 and others have been ... -
Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies
(Taylor and Francis Ltd., 2020)Coronaviruses are contagious pathogens primarily responsible for respiratory and intestinal infections. Research efforts to develop antiviral agents against coronavirus demonstrated the main protease (Mpro) protein may ... -
Mechanisms of Anti-Tumor Activity of Withania somnifera (Ashwagandha)
(Routledge, 2020)Increasing herbal formulations have been used to treat several diseases including cancer. W. somnifera (Ashwagandha) is one such plant the extracts of which have been tested against a number of ailments including cancer, ... -
miRNA dysregulation in ischaemic stroke: Focus on diagnosis, prognosis, therapeutic and protective biomarkers
(Blackwell Publishing Ltd, 2020)Stroke is one of the leading causes of death and disability in both developing and developed countries. Biomarkers for stroke and its outcome can greatly facilitate early detection and management of the disease. miRNAs ... -
Combinatorial Effect of DCA and Let-7a on Triple-Negative MDA-MB-231 Cells: A Metabolic Approach of Treatment
(SAGE Publications Inc., 2020)Dichloroacetate (DCA) is a metabolic modulator that inhibits pyruvate dehydrogenase activity and promotes the influx of pyruvate into the tricarboxylic acid cycle for complete oxidation of glucose. DCA stimulates oxidative ... -
Establishing molecular signatures of stroke focusing on omic approaches: a narrative review
(Taylor and Francis Ltd, 2020)Stroke or �brain attack� is considered to be the major cause of mortality and morbidity worldwide after myocardial infraction. Inspite of the years of research and clinical practice, the pathogenesis of stroke still remains ... -
Anti-cancer drug doxorubicin induced cardiotoxicity: Understanding the mechanisms involved in ros generation resulting in mitochondrial dysfunction
(Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma, 2020)Doxorubicin (DOX), despite being an effective anti-cancer drug has offsite targets that affect the vital organs such as heart, brain and kidney. DOX-induced cardiotoxicity is reported as a multi-factorial process that ... -
Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human
(Springer, 2020)At present, more than 200 countries and territories are directly affected by the coronavirus disease-19 (COVID-19) pandemic. Incidence and case fatality rate are significantly higher among elderly individuals (age > 60 ... -
E-pharmacophore guided discovery of pyrazolo[1,5-c]quinazolines as dual inhibitors of topoisomerase-I and histone deacetylase
(Academic Press Inc., 2020)In the quest to ameliorate the camptothecin (CPT) downsides, we expedite to search for stable non-CPT analogues among 11 motifs of pyrazoloquinazolines reported. E-pharmacophore drug design approach helped filtering out ... -
Correction to: Association of the genetic variants of insulin receptor substrate 1 (IRS-1) with type 2 diabetes mellitus in a Saudi population (Endocrine, (2014), 47, 2, (472-477), 10.1007/s12020-014-0177-2)
(Springer, 2020)Type 2 diabetes mellitus (T2DM) is a chronic degenerative disease, phenotypically and genetically heterogeneous, characterized by high levels of glucose and metabolic complications. Insulin receptor substrate 1 (IRS-1) ... -
P53-mediated anticancer activity of Citrullus colocynthis extracts
(Bentham Science Publishers, 2019)Background: Current anticancer therapeutics comes with significant side effects and thus focus is shifting towards minimizing the side effects or to avoid the disease altogether. Thus, various natural products are being ... -
Small regulatory molecules acting big in cancer: Potential role of mito-miRs in cancer
(Bentham Science Publishers, 2019)MicroRNAs [miRNAs] are short, non-coding, single stranded RNA molecules regulating gene expression of their targets at the posttranscriptional level by either degrading mRNA or by inhibiting translation. Previously, miRNAs ... -
Human-lymphocyte cell friendly starch-hydroxyapatite biodegradable composites: Hydrophilic mechanism, mechanical, and structural impact
(John Wiley and Sons Inc., 2019)Biodegradable starch (Str) polymer was derived from potato, a plant-based natural carbohydrate polymers source, by one-pot synthesis. Hydroxyapatite (HA) was produced from goat bone by step sintering. The inexpensive ... -
Caulerpa taxifolia inhibits cell proliferation and induces oxidative stress in breast cancer cells
(De Gruyter, 2019)Caulerpa taxifolia (M. Vahl) C. Agardh or killer alga is known to possess several bioactive secondary metabolites with unique structural modifications. We investigated anti-oxidant and anti-proliferative activity of C. ... -
ACE-Triggered Hypertension Incites Stroke: Genetic, Molecular, and Therapeutic Aspects
(Springer, 2019)Stroke is the second largest cause of death worldwide. Angiotensin converting enzyme (ACE) gene has emerged as an important player in the pathogenesis of hypertension and consequently stroke. It encodes ACE enzyme that ... -
Association of elevated levels of C-reactive protein with breast cancer, breast cancer subtypes, and poor outcome
(Mosby Inc., 2019)Background and Purpose: Inflammation and caner are linked in a bidirectional manner. C-reactive protein (CRP) is an important inflammatory marker. The aim of the study was to test whether the inflammatory marker, CRP at ... -
Genetics of platelet traits in ischaemic stroke: focus on mean platelet volume and platelet count
(Taylor and Francis Ltd, 2019)Purpose/Aim of the study: The aim of this review is to summarize the role of genetic variants affecting mean platelet volume (MPV) and platelet count (PLT) leading to higher platelet reactivity and in turn to thrombotic ...
