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Association of CYP2C19*2 and ALDH1A1*1/*2 variants with disease outcome in breast cancer patients: results of a global screening array
(Springer Verlag, 2018)
Purpose: Cyclophosphamide and doxorubicin (adjuvant chemotherapy) are commonly used to treat breast cancer patients. Variation in the genes involved in pharmacodynamics and pharmacokinetics of these drugs plays an important ...
Recent advances in HER2 positive breast cancer epigenetics: Susceptibility and therapeutic strategies
(Elsevier Masson SAS, 2017)
HER2 amplification/overexpression accounts for aggressive clinical features of HER2 positive breast cancer. Epigenetic changes including DNA methylation, histone modifications and ncRNAs/miRNAs are associated with regulation ...
Assessment of Resting-state functional Magnetic Resonance Imaging Connectivity Among Patients with Major Depressive Disorder: A Comparative Study
(SAGE Publications Inc., 2023-08-29)
Background: Resting-state functional connectivity analysis has a potential to unearth the putative neuronal underpinnings of various disorders of the brain. Major depressive disorder (MDD) is regarded as a disorder arising ...
Genomic Variation Affecting MPV and PLT Count in Association with Development of Ischemic Stroke and Its Subtypes
(Springer, 2023-07-15)
Platelets play a significant role in the pathophysiology of ischemic stroke since they are involved in the formation of intravascular thrombus after erosion or rupture of the atherosclerotic plaques. Platelet (PLT) count ...
Advanced molecular therapies for neurological diseases: focus on stroke, alzheimer's disease, and parkinson's disease
(Springer-Verlag Italia s.r.l., 2022-09-06)
Neurological diseases (NDs) are one of the leading causes of disability and the second leading cause of death globally. Among these stroke, Alzheimer's disease (AD), and Parkinson's disease (PD) are the most common NDs. A ...
Role of Omics in Migraine Research and Management: A Narrative Review
(Springer, 2022-07-07)
Migraine is a neurological disorder defined by episodic attacks of chronic pain associated with nausea, photophobia, and phonophobia. It is known to be a complex disease with several environmental and genetic factors ...
Neuroimaging Genomics a Predictor of Major Depressive Disorder (MDD)
(Springer, 2023-11-22)
Depression is a complex psychiatric disorder influenced by various genetic and environmental factors. Strong evidence has established the contribution of genetic factors in depression through twin studies and the heritability ...
Common microRNAs in Epilepsy and Migraine: Their Possibility as Can-didates for Biomarkers and Therapeutic Targets during Comorbid Onset of Both Conditions
(Bentham Science Publishers, 2022-04-27)
Epilepsy and migraine are chronic neurological disorders with shared clinical as well as pathophysiological mechanisms. Epileptic patients are at a higher risk of developing migraine compared to normal individuals and vice ...
Epilepsy and Migraine Shared Genetic and Molecular Mechanisms: Focus on Therapeutic Strategies
(Springer, 2021-04-15)
Epilepsy and migraine are both episodic disorders and share clinical as well as pathophysiological mechanisms. The prevalence of epilepsy in migraine patients is generally higher than normal as compared to general population ...
Currently available COVID-19 management options
(Elsevier, 2023-01-20)
The pandemic caused by new coronavirus (COVID-19), i.e., severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), started from the Wuhan state of China. COVID-19 is a novel infectious disease characterized by atypical ...