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Systematic review and meta-analysis to establish the association of common genetic variations in Vitamin D binding protein with chronic obstructive pulmonary disease
(Frontiers Media S.A., 2019)
Background: Vitamin-D binding protein (DBP) also known as GC protein, is a major determinant for vitamin- D metabolism and transport. GC1F, GC1S, and GC2 are the three allelic variants (denoted as rs4588 and rs7041) of GC, ...
Systematic review and meta-analysis confirms significant contribution of surfactant protein D in chronic obstructive pulmonary disease
(Frontiers Media S.A., 2019)
Background: Surfactant protein D (SFTPD) is a lung specific protein which performs several key regulatory processes to maintain overall lung function. Several infectious and immune mediated diseases have been shown to be ...
Serum homocysteine could be used as a predictive marker for chronic obstructive pulmonary disease: A meta-analysis
(Frontiers Media S.A., 2019)
Background: Serum homocysteine (Hcy) level is inversely related with concentration of folic acid, which is an essential micronutrient for metabolism and energy homeostasis. Serum concentrations of Hcy have been reported ...
Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies
(Taylor and Francis Ltd., 2020-06-01)
Coronaviruses are contagious pathogens primarily responsible for respiratory and intestinal infections. Research efforts to develop antiviral agents against coronavirus demonstrated the main protease (Mpro) protein may ...
Contributions of human ACE2 and TMPRSS2 in determining host�pathogen interaction of COVID-19
(Springer, 2021-02-25)
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is at present an emerging global public health crisis. Angiotensin converting enzyme 2 (ACE2) and trans-membrane protease serine 2 (TMPRSS2) are the ...
Obesity-Induced Chronic Low-Level Inflammation and Cancers
(Springer Singapore, 2021-07-18)
The World Health Organization (WHO) has highlighted �overweight and obesity� as a public health concern and a significant risk factor for several chronic diseases, including diabetes, cardiovascular diseases, and cancers. ...
mTOR and AMP-Activated Protein Kinase in Obesity and Cancer
(Springer Singapore, 2021-07-18)
The mTOR (mechanistic target of rapamycin) is the main regulator of important cellular processes, including cellular growth, proliferation, protein synthesis, protein remodeling, autophagy, and cell metabolism in response ...
Epidemiology and genetics of granulomatosis with polyangiitis
(Springer Science and Business Media Deutschland GmbH, 2021-10-11)
Granulomatosis with polyangiitis (GPA) previously known as Wegener�s granulomatosis (WG)�is a rare rheumatic disease affecting subjects of all ages. Prevalence and incidence of this systemic disease greatly varies across ...
FTIR based approach to study EnaC mechanosensory functions
(Elsevier Ltd, 2021-07-19)
The pulmonary epithelial sodium ion channel (ENaC) is gaining importance for its sodium gating and mechanosensitive roles. The mechano functional studies on ENaC suggest direct molecular interactions between the ENaC protein ...
Withania somnifera phytochemicals possess SARS-CoV-2 RdRp and human TMPRSS2 protein binding potential
(Springer, 2022-06-15)
Abstract: Coronavirus disease-19 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has infected approximately 26�million people and caused more than 6�million deaths globally. Spike ...