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APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups
(BioMed Central Ltd, 2021-09-21)
Background: Hypertriglyceridemia has emerged as a critical coronary artery disease (CAD) risk factor. Rare loss-of-function (LoF) variants in apolipoprotein C-III have been reported to reduce triglycerides (TG) and are ...
Large-Scale Characterization of the Soil Microbiome in Ancient Tea Plantations Using High-Throughput 16S rRNA and Internal Transcribed Spacer Amplicon Sequencing
(Frontiers Media S.A., 2021-10-16)
There is a special interaction between the environment, soil microorganisms, and tea plants, which constitute the ecosystem of tea plantations. Influenced by environmental factors and human management, the changes in soil ...
Obesity-Induced Chronic Low-Level Inflammation and Cancers
(Springer Singapore, 2021-07-18)
The World Health Organization (WHO) has highlighted �overweight and obesity� as a public health concern and a significant risk factor for several chronic diseases, including diabetes, cardiovascular diseases, and cancers. ...
mTOR and AMP-Activated Protein Kinase in Obesity and Cancer
(Springer Singapore, 2021-07-18)
The mTOR (mechanistic target of rapamycin) is the main regulator of important cellular processes, including cellular growth, proliferation, protein synthesis, protein remodeling, autophagy, and cell metabolism in response ...
Epidemiology and genetics of granulomatosis with polyangiitis
(Springer Science and Business Media Deutschland GmbH, 2021-10-11)
Granulomatosis with polyangiitis (GPA) previously known as Wegener�s granulomatosis (WG)�is a rare rheumatic disease affecting subjects of all ages. Prevalence and incidence of this systemic disease greatly varies across ...
Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4
(BioMed Central Ltd, 2021-11-27)
Background and objectives: MicroRNA (miRNA) that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNA (mitomiR). Albeit mitomiRs have been shown to modulate gene expression, their functional ...
Gene-editing, immunological and iPSCs based therapeutics for muscular dystrophy
(Elsevier B.V., 2021-10-15)
Muscular dystrophy is a well-known genetically heterogeneous group of rare muscle disorders. This progressive disease causes the breakdown of skeletal muscles over time and leads to grave weakness. This breakdown is caused ...
FTIR based approach to study EnaC mechanosensory functions
(Elsevier Ltd, 2021-07-19)
The pulmonary epithelial sodium ion channel (ENaC) is gaining importance for its sodium gating and mechanosensitive roles. The mechano functional studies on ENaC suggest direct molecular interactions between the ENaC protein ...
Measuring routine childhood vaccination coverage in 204 countries and territories, 1980�2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1
(Elsevier B.V., 2021-07-21)
Background: Measuring routine childhood vaccination is crucial to inform global vaccine policies and programme implementation, and to track progress towards targets set by the Global Vaccine Action Plan (GVAP) and Immunization ...
Microglia Specific Drug Targeting Using Natural Products for the Regulation of Redox Imbalance in Neurodegeneration
(Frontiers Media S.A., 2021-04-13)
Microglia, a type of innate immune cell of the brain, regulates neurogenesis, immunological surveillance, redox imbalance, cognitive and behavioral changes under normal and pathological conditions like Alzheimer�s, ...