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Recent developments of C-4 substituted coumarin derivatives as anticancer agents
(Elsevier Masson SAS, 2016)
Cancer is a prominent cause of death in global. Currently, the numbers of drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand ...
Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies
(Elsevier Masson SAS, 2015)
Abstract Coumarins are fused benzene and pyrone ring systems which prompt biological investigation to assess their potential therapeutic significance. It possesses immeasurable anticancer potential with minimum side effects ...
Thiazole and Related Heterocyclic Systems as Anticancer Agents: A Review on Synthetic Strategies, Mechanisms of Action and SAR Studies
(Bentham Science Publishers, 2022-03-21)
Background: Cancer is the second leading cause of death worldwide. Many anticancer drugs are commercially available, but lack of selectivity, target specificity, cytotoxicity, and development of resistance lead to serious ...
Synthesis, in vitro, and docking analysis of c-3 substituted coumarin analogues as anticancer agents
(Bentham Science Publishers, 2020-01-28)
Background: Breast cancer (BC) is a leading cause of cancer-related deaths in women next to skin cancer. Estrogen receptors (ERs) play an important role in the progression of BC. Current anticancer agents have several ...
Synthesis and In Silico Studies of C-4 Substituted Coumarin Analogues as Anticancer Agents
(Bentham Science Publishers, 2020-06-29)
Background: Coumarin is a fused ring system and possesses the enormous capability of targeting various receptors participating in the cancer pathway. Coumarin and its derivatives were found to exhibit very rare toxicity ...