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Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement
(Academic Press, 2020)
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is an ester of epigallocatechin and gallic acid. EGCG, abundantly found in tea, is a polyphenolic flavonoid that has the potential to affect human ...
Molecular docking and in vitro study of Syzygium cumini-derived natural compounds on receptor tyrosine kinases pathway components
(Inderscience Enterprises Ltd., 2019)
Syzygium cumini (S. cumini) is used for a variety of biological activities such as anti-inflammatory, anti-diabetic and anti-oxidant; currently, it has been reported for DNA protecting activity against radiation damage. ...
Molecular mechanisms of action of genistein in cancer: Recent advances
(Frontiers Media S.A., 2019)
Background: Genistein is one among the several other known isoflavones that is found in different soybeans and soy products. The chemical name of genistein is 4?,5,7-trihydroxyisoflavone. Genistein has drawn attention of ...
Epidermal growth factor receptor and its trafficking regulation by acetylation: Implication in resistance and exploring the newer therapeutic avenues in cancer
(Bentham Science Publishers, 2020)
Background: The EGFR is overexpressed in numerous cancers. So, it becomes one of the most favorable drug targets. Single-acting EGFR inhibitors on prolong use induce resistance and side effects. Inhibition of EGFR and/or ...
Insilco Molecular Docking Study of Natural Compounds On Wild and Mutated Epidermal Growth Factor Receptor
(Springer, 2014)
The role played by overexpression of tyrosine kinase epidermal growth factor receptor (EGFR), the transmembrane receptor central to numerous cellular processes comprising cell migration, adhesion, apoptosis, and cell ...
Dihydropyrimidine dehydrogenase in the metabolism of the anticancer drugs
(Springer Verlag, 2019)
Cancer caused by fundamental defects in cell cycle regulation leads to uncontrolled growth of cells. In spite of the treatment with chemotherapeutic agents of varying nature, multiple resistance mechanisms are identified ...
Antioxidant potential of ganoderic acid in Notch-1 protein in neuroblastoma
(Springer New York LLC, 2019)
Neuroblastoma is a childhood tumor arising from developing a sympathetic nervous system and causes around 10% of pediatric tumors. Despite advancement in the use of sophisticated techniques in molecular biology, neuroblastoma ...
Caulerpa taxifolia inhibits cell proliferation and induces oxidative stress in breast cancer cells
(De Gruyter, 2019)
Caulerpa taxifolia (M. Vahl) C. Agardh or killer alga is known to possess several bioactive secondary metabolites with unique structural modifications. We investigated anti-oxidant and anti-proliferative activity of C. ...
Steering the antitumor drug discovery campaign towards structurally diverse indolines
(Academic Press Inc., 2020)
Indoline framework is often perpended as a privileged heterocycle present in medicinally valuable compounds of natural and synthetic origin. This review article presents the rational approaches/strategies employed for the ...
Legume lectins: Potential use as a diagnostics and therapeutics against the cancer
(Elsevier B.V., 2020)
Legume lectins are carbohydrate-binding protein and widely distributed in a variety of species of leguminous plants and have drawn increased attention toward cancer. Nowadays, the lectins have been studied for the screening ...