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Multitargeted molecular docking study of natural-derived alkaloids on breast cancer pathway components
(Bentham Science Publishers B.V., 2017)
Background: Targeting of multiple sites is a pharmacologically, pharmacokinetic and dynamically more acceptable approach for complex diseases such as BC. It is recommended that the women who are at high risk of developing ...
In silico screening and molecular interaction studies of tetrahydrocannabinol and its derivatives with acetylcholine binding protein
(Bentham Science Publishers B.V., 2018)
Background: Alzheimer’s disease (AD) is the fourth largest cause of death among people over 65 years of age. Accumulation of β-amyloid and cholinergic deficiency are two prominent pathological descriptions for AD.
Objective: ...
Identification of novel indole based heterocycles as selective estrogen receptor modulator.
(Elsevier, 2018)
In the present study, we have designed and synthesized indole derivatives by coalescing the indole nucleus with chromene carbonitrile and dihydropyridine nucleus. Two compounds 5c and 6d were selected from series I and II ...
Recent Advances in Plant Metabolites Analysis, Isolation, and Characterization
(Springer, 2018)
Metabolites from natural sources either from terrestrial or marine sources serve as unmatched resources for new drug leads or diverse chemical identity. Due to ever-rising requirement for new pharmacophore in high-throughput ...
Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review.
(Bentham Science, 2018)
Background: The prevalence of lung cancer is 14% among the newly diagnosed cancer cases worldwide. Currently, the number of drugs that are in clinical practice is having a high prevalence of side effect and multidrug ...
Synthesis, in vitro, and docking analysis of c-3 substituted coumarin analogues as anticancer agents
(Bentham Science Publishers, 2020-01-28)
Background: Breast cancer (BC) is a leading cause of cancer-related deaths in women next to skin cancer. Estrogen receptors (ERs) play an important role in the progression of BC. Current anticancer agents have several ...