Browsing School of Health Sciences by Subject "Alzheimer's disease"
Now showing items 1-8 of 8
-
Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases
(John Wiley and Sons Inc, 2023-05-03)The blood platelet plays an important role but often remains under-recognized in several vascular complications and associated diseases. Surprisingly, platelet hyperactivity and hyperaggregability have often been considered ... -
Apoptosis in Alzheimer�s disease: insight into the signaling pathways and therapeutic avenues
(Springer, 2023-04-26)Alzheimer�s disease (AD) is characterized by the accumulation of hyperphosphorylated tau and amyloid-? (A?) protein resulting in synaptic loss and apoptosis. A? and tau deposition trigger apoptotic pathways that result in ... -
Endoplasmic reticulum stress in Alzheimer's disease: Molecular mechanisms and therapeutic prospects
(Elsevier Inc., 2023-07-29)Alzheimer's disease (AD) is a progressive neurodegenerative condition that leads to memory loss and cognitive impairment over time. It is characterized by protein misfolding as well as prolonged cellular stress, such as ... -
Insights into receptor tyrosine kinases signaling in neurodegenerative disorders: opportunities and translational perspectives
(Elsevier, 2023-07-06)Receptor tyrosine kinases (RTKs) are a group of membrane-bound receptors comprising of extracellular ligand-binding domain, a transmembrane domain, and an intracellular catalytic domain. RTKs play a crucial role in various ... -
Redefining oxidative stress in Alzheimer's disease: Targeting platelet reactive oxygen species for novel therapeutic options
(Elsevier Inc., 2022-08-01)Alzheimer's disease (AD), a progressive neurodegenerative disorder, is considered one of the most common causes of dementia worldwide, accounting for about 80 % of all dementia cases. AD is manifested by the extraneuronal ... -
Stem cells in the treatment of Alzheimer's disease � Promises and pitfalls
(Elsevier B.V., 2023-04-06)Alzheimer's disease (AD) is the most widespread form of neurodegenerative disorder that causes memory loss and multiple cognitive issues. The underlying mechanisms of AD include the build-up of amyloid-? and phosphorylated ... -
Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease
(Elsevier B.V., 2023-06-29)Alzheimer's disease (AD) is a neurodegenerative disease that manifests its pathology through synaptic damage, mitochondrial abnormalities, microRNA deregulation, hormonal imbalance, increased astrocytes & microglia, ... -
Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer's disease
(Elsevier B.V., 2023-09-13)Synaptic mitochondria are crucial for maintaining synaptic activity due to their high energy requirements, substantial calcium (Ca2+) fluctuation, and neurotransmitter release at the synapse. To provide a continuous energy ...