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Differential molecular mechanistic behavior of HDACs in cancer progression
(Springer, 2022-08-16)
Genetic aberration including mutation in oncogenes and tumor suppressor genes transforms normal cells into tumor cells. Epigenetic modifications work concertedly with genetic factors in controlling cancer development. ...
�The pharmacological profile of SGLT2 inhibitors: Focus on mechanistic aspects and pharmacogenomics�
(Elsevier B.V., 2021-05-11)
Diabetes, characterized by high glucose levels, has been listed to be one of the world's major causes of death. Around 1.6 million deaths are attributed to this disease each year. Persistent hyperglycemic conditions in ...
Role of miRNAs in diabetic neuropathy: mechanisms and possible interventions
(Springer, 2022-01-13)
Accelerating cases of diabetes worldwide have given rise to higher incidences of diabetic complications. MiRNAs, a much-explored class of non-coding RNAs, play a significant role in the pathogenesis of diabetes mellitus ...
miRNA signatures in diabetic retinopathy and nephropathy: delineating underlying mechanisms
(Springer Science and Business Media B.V., 2022-01-31)
A worldwide failure to achieve glycemic targets has led to complications associated with diabetes mellitus. In addition to genetic and other risk factors, epigenetic factors like DNA methylation, histone modifications, and ...