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Now showing items 1345-1364 of 3506
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Genetic Understanding of Stroke Treatment: Potential Role for Phosphodiesterase Inhibitors
(Springer New York LLC, 2017)Phosphodiesterase (PDE) gene family is a large family having at least 21 genes and multiple versions (isoforms) of the phosphodiesterase enzymes. These enzymes catalyze the inactivation of intracellular mediators of signal ... -
Genetic variants of metabolism and inflammatory pathways, and PCOS risk �Systematic review, meta-analysis, and in-silico analysis
(Elsevier B.V., 2023-09-14)Importance: Identification of genetic risk factors for PCOS susceptibility. Objective: To identify genetic risk variants of the genes involved in metabolic or inflammatory pathways. Data sources: Relevant literature was ... -
Genetic Variants of Steroidogenesis and Gonadotropin Pathways and Polycystic Ovary Syndrome Susceptibility: A Systematic Review and Meta-analysis
(Mary Ann Liebert Inc., 2023-10-25)Genetic variants are predisposing factors to polycystic ovary syndrome (PCOS), a multifactorial condition that often gets triggered due to various environmental factors. The study investigates the association of the variants ... -
Genetic variations in tumor-suppressor miRNA-encoding genes and their target genes: focus on breast cancer development and possible therapeutic strategies
(Springer Science and Business Media Deutschland GmbH, 2023-04-24)MicroRNAs (miRNAs) negatively affect gene expression by binding to their specific mRNAs resulting in either mRNA destruction or translational repression. The aberrant expression of various miRNAs has been associated with ... -
Genetically modified crop regulations: scope and opportunity using the CRISPR-Cas9 genome editing approach
(Springer Science and Business Media B.V., 2021-06-10)Global demand for food is increasing day by day due to an increase in population and shrinkage of the arable land area. To meet this increasing demand, there is a need to develop high-yielding varieties that are nutritionally ... -
Genetically modified crop regulations: scope and opportunity using the CRISPR-Cas9 genome editing approach
(Springer Science and Business Media B.V., 2021-06-10)Global demand for food is increasing day by day due to an increase in population and shrinkage of the arable land area. To meet this increasing demand, there is a need to develop high-yielding varieties that are nutritionally ... -
Genetics of idiopathic generalized epilepsy: An overview
(Neurology Society of India, 2014)Idiopathic generalized epilepsy (IGE) is a common type of epilepsy. Strong support for a genetic role in IGE comes from twin and family studies. Several subtypes of IGE have been reported but families often have members ... -
Genetics of platelet traits in ischaemic stroke: focus on mean platelet volume and platelet count
(Taylor and Francis Ltd, 2019)Purpose/Aim of the study: The aim of this review is to summarize the role of genetic variants affecting mean platelet volume (MPV) and platelet count (PLT) leading to higher platelet reactivity and in turn to thrombotic ... -
A genome editing approach to enhance host resistance against plant-parasitic weeds
(Nova Science Publishers, Inc., 2023-08-14)Root-specific plant-parasitic weeds Phelipanche and Orobanche spp. (broomrape) induce potential damage to numerous crops and lead to heavy loss to the economy due to a reduction in total yield, especially in the Mediterranean, ... -
Genome recoding strategies to improve cellular properties: mechanisms and advances
(Springer, 2020-11-19)The genetic code, once believed to be universal and immutable, is now known to contain many variations and is not quite universal. The basis for genome recoding strategy is genetic code variation that can be harnessed to ... -
Genome recoding strategies to improve cellular properties: mechanisms and advances
(Springer, 2020-11-19)The genetic code, once believed to be universal and immutable, is now known to contain many variations and is not quite universal. The basis for genome recoding strategy is genetic code variation that can be harnessed to ... -
Genome recoding: a review of basic concepts, current research and future prospects of virus attenuation for controlling plant viral diseases
(Springer, 2020-08-10)Plants are very susceptible to pathogens and every year, 25% of crop loss is caused by various types of pathogens including viruses. Many different strategies are being used for developing resistance against virus infection, ... -
Genome recoding: a review of basic concepts, current research and future prospects of virus attenuation for controlling plant viral diseases
(Springer, 2020-08-10)Plants are very susceptible to pathogens and every year, 25% of crop loss is caused by various types of pathogens including viruses. Many different strategies are being used for developing resistance against virus infection, ... -
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
(Nature Publishing Group, 2016)Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis ... -
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India
(American Diabetes Association Inc., 2013)We performed a genome-wide association study (GWAS) and a multistage meta-analysis of type 2 diabetes (T2D) in Punjabi Sikhs from India. Our discovery GWAS in 1,616 individuals (842 case subjects) was followed by in silico ... -
Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study
(Elsevier Ltd, 2016)Vitamin D deficiency is implicated in multiple disease conditions and accumulating evidence supports that the variation in serum vitamin D (25(OH)D) levels, including deficiency, is under strong genetic control. However, ... -
Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans
(Impact Journals LLC, 2015)Lowering insulin-IGF-1-like signalling (IIS) activates FOXO transcription factors (TF) to extend life span across species. To study the dynamics of FOXO chromatin occupancy under this condition in C. elegans, we report the ... -
Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans
(Impact Journals, 2015)Lowering insulin-IGF-1-like signalling (IIS) activates FOXO transcription factors (TF) to extend life span across species. To study the dynamics of FOXO chromatin occupancy under this condition in C. elegans, we report the ... -
Genome-wide identification and gene expression analysis of GHMP kinase gene family in banana cv. Rasthali
(Springer Science and Business Media B.V., 2023-09-20)Background: The GHMP kinase gene family encompasses ATP-dependent kinases, significantly involved in the biosynthesis of isoprenes, amino acids, and metabolism of carbohydrates. Banana is a staple tropical crop that is ... -
Genome-wide identification and gene expression analysis of GHMP kinase gene family in banana cv. Rasthali
(Springer Science and Business Media B.V., 2023-09-20)Background: The GHMP kinase gene family encompasses ATP-dependent kinases, significantly involved in the biosynthesis of isoprenes, amino acids, and metabolism of carbohydrates. Banana is a staple tropical crop that is ...