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Expression analysis of long non-coding RNA GAS5 and BANCR in lung cancer cell line A549 compared to IMR-90.
(Central University of Punjab, 2018)
Lung cancer is the major cause of death worldwide. Several chemotherapeutic drugs and therapies have been established, but the early diagnosis and prognosis of lung cancer is still a question. Long non-coding RNAs are ...
To Test The Role Of Withaferin A In Neuroprotection On Sh-Sy5Y Cell Line Challenged By Kainic Acid
(Central University of Punjab, 2018)
Withania somnifera (WS) has been used in traditional medicine for a variety of neural disorders. Recently, chronic neurodegenerative conditions have been shown to benefit from treatment with this crude extract. Neurotoxicity ...
Isolation and characterization of platelet microvesicles
(Central University of Punjab, 2018)
In the recent years, Platelet microvesicles (PMVs) are projected as potential diagnostic and prognostic biomarkers of many diseases like cardiovascular diseases, diabetes and infection. Due to the small size (100-1000 nm), ...
Traumatic Brain Injury (TBI) causes hypersomnia in Drosophila melanogaster
(Central University of Punjab, 2018)
Traumatic brain injury (TBI) is one of the deadly event which is a leading cause of neurological impairments and loss of life. The TBI outcomes arise from primary and secondary injuries. It damages neurons as well as causes ...
Role of midgut digestive proteases upon sub-lethal exposure of Cry toxin in the larvae of castor semilooper, Achaea janata
(Central University of Punjab, 2018)
Development of synthetic insecticides to reduce the level of infestation led to deleterious effects on the environment and human health. This lead to the development of eco-friendly pest management alternatives including ...
Oxidative stress responses to sub-lethal dose of Cry toxin in the larvae of castor semilooper, Achaea janata
(Central University of Punjab, 2018)
Development of synthetic insecticides to reduce the level of infestation led to deleterious effects on environment and human health. This lead to the development of ecofriendly pest management alternatives including Bacillus ...
Oxidative stress stimulates invasive potential in rat C6 and human U-87 MG glioblastoma cells via activation and cross-talk between PKM2, ENPP2 and APE1 enzymes.
(Springer, 2018)
Maintaining genomic integrity is essential for cell survival and viability. Reactive oxygen species (ROS) overproduction results in oxidative stress leading to the genomic instability via generation of small base lesions ...
Hormones of hypothalamus and ageing
(Springer, 2018)
Hypothalamus being the master regulator of the vertebrate endocrine system undergoes many adjustments/alterations which body makes during the course of aging. Moreover, the endocrinological basis of aging in male and female ...
Anticancer activity of dihydropyrazolo[1,5-c]quinazolines against rat C6 glioma cells via inhibition of topoisomerase II.
(Wiley, 2018)
The design and synthesis of dihydropyrazolo[1,5‐c]quinazolines (1a–h) as human topoisomerase II (TopoII) catalytic inhibitors are reported. The compounds were investigated for their antiproliferative activity against the ...
Pseudomonas aeruginosa quorum sensing molecule N-3-oxo-dodecanoyl-Lhomoserine lactone activates human platelets through intracellular calciummediated ROS generation
(Elsevier, 2018)
Pseudomonas aeruginosa, an opportunistic pathogen release N-3-oxo-dodecanoyl-l-homoserine lactone (3-oxo-C12HSL) and N-butyryl-l-homoserine lactone (C4-HSL) quorum sensing (QS) molecules to regulate various virulence factors ...