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Novel potent inhibitors of Plasmodium vivax dihydrofolate reductase: An in silico antimalarial drug discovery
(Association of Pharmaceutical Teachers of India, 2018)
Objectives: In the present study, we targeted the dihydrofolate reductase enzyme that catalyzes the reduction of dihydrofolate to tetrahydrofolate which is required for the purines and pyrimidine synthesis. Malaria is one ...
miR-301, pleiotropic MicroRnA in Regulation of inflammatory Bowel Disease and ColitisAssociated Cancer
(Frontiers in Immunology, 2018)
Inflammatory bowel disease (IBD) is a chronic idiopathic, relapsing, and remitting immune disorders of gastrointestinal tract which consist of two forms, i.e., Crohn’s disease (affect the whole gastrointestinal tract) and ...
Nischarin regulates focal adhesion and Invadopodia formation in breast cancer cells
(BioMed Central Ltd., 2018)
Background: During metastasis, tumor cells move through the tracks of extracellular matrix (ECM). Focal adhesions (FAs) are the protein complexes that link the cell cytoskeleton to the ECM and their presence is necessary ...
Association of elevated levels of C-reactive protein with breast cancer, breast cancer subtypes, and poor outcome
(Mosby Inc., 2018)
Background and Purpose: Inflammation and caner are linked in a bidirectional manner. C-reactive protein (CRP) is an important inflammatory marker. The aim of the study was to test whether the inflammatory marker, CRP at ...
Inflammatory response of gliadin protein isolated from various wheat varieties on human intestinal cell line
(Academic Press, 2018)
Wheat protein contributes a significant part in human diet, apart from its well-known nutritional values, wheat gluten/gliadin proteins are also responsible for the many allergic/inflammatory diseases and chronic inflammation ...
Polydopamine films change their physicochemical and antimicrobial properties with a change in reaction conditions
(Royal Society of Chemistry, 2018)
The morphology and physicochemical properties of polydopamine are not totally inherent and undergo changes with differing reaction conditions like the choice of solvent used for polymerization. The polymerisation of dopamine ...
Role of immune system in tumor progression and carcinogenesis
(Wiley-Liss Inc., 2018)
Tumor micro-environment has potential to customize the behavior of the immune cell according to their need. In immune-eliminating phase, immune cells eliminate transformed cells but after tumor establishment innate and ...
Design, synthesis and biological evaluation of novel indole-xanthendione hybrids as selective estrogen receptor modulators
(Elsevier Ltd, 2018)
Ground breaking clinical therapeutic advances in the treatment of breast cancer (BC) is the introduction of selective estrogen receptor modulators (SERMs). We have expeditiously designed and synthesized indole-xanthendione ...
Identification of Novel Natural Inhibitors Of Proteins Involved In Cancer Cell Stemness
(Central University of Punjab, 2018)
Cancer stem cells (CSCs) are a small subpopulation of cells identified in a variety of tumors that are capable of self-renewal, differentiation and have the unique property to evade radiotherapy and chemotherapy. CSCs are ...
Identification of natural inhibitors of proteins involved in the pathology of Parkinson's disease
(Central University of Punjab, 2018)
Parkinson's disease (PD) is a progressive neurodegenerative disorder caused due to the lack of dopamine in the brain. Different drug therapies are available for PD showing excellent efficiency, but most of them are cost ...