Browsing Biochemistry and Microbial Sciences-Research Publications by Author "Kushwaha, Prem Prakash"
Now showing items 1-20 of 21
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Ancistrobrevinium A, the first N-methylated, cationic naphthylisoquinoline alkaloid, from the tropical liana Ancistrocladus abbreviatus (Ancistrocladaceae)
Tajuddeen, Nasir; Fayez, Shaimaa; Kushwaha, Prem Prakash; Feineis, Doris; Ak� Assi, Laurent; Kumar, Shashank; Bringmann, Gerhard (Taylor and Francis Ltd., 2023-03-29)Ancistrobrevinium A (1) is the first N-methylated and non-hydrogenated, and thus cationic naphthylisoquinoline alkaloid. It was discovered in the root bark extract of the phytochemically productive West African liana ... -
Anti-proliferative, apoptosis inducing, and antioxidant potential of Callistemon lanceolatus bark extracts: an in vitro and in silico study
Kumar, Ramesh; Kushwaha, Prem Prakash; Singh, Atul Kumar; Kumar, Shashank; Pandey, Abhay Kumar (Springer, 2023-05-08)The present study reports anticancer and antioxidant activities of Callistemon lanceolatus bark extracts. Anticancer activity was studied against MDA-MB-231 cells. Antioxidant assessment of the chloroform and methanol ... -
Bulbine frutescens phytochemicals as novel ABC-transporter inhibitor: A molecular docking and molecular dynamics simulation study
Kushwaha, Prem Prakash; Maurya, Santosh Kumar; Singh, Amit; Prajapati, Kumari Sunita; Singh, Atul Kumar; Shuaib, Mohd; Kumar, Shashank (OAE Publishing Inc., 2021-01-08)Aim: The present in silico study aimed to evaluate the ATP-binding cassette (ABC) transporter inhibition potential of Bulbine frutescens (B. frutescens) phytochemicals. Methods: Several previous studies and databases were ... -
Characterization of phytochemicals and validation of antioxidant and anticancer activity in some Indian polyherbal ayurvedic products
Kushwaha, Prem Prakash; Kumar, Ramesh; Neog, Panchi Rani; Behara, Malay Ranjan; Singh, Pratibha; Kumar, Ajay; Prajapati, Kumari Sunita; Singh, Atul Kumar; Shuaib, Mohd; Sharma, Amit Kumar; Pandey, Abhay Kumar; Kumar, Shashank (Springer, 2021-03-13)In the present comparative study, the authors studied the antioxidant and anticancer activity of commercially available polyherbal Indian Ayurvedic products namely Divya Sarvakalp Kwath (DSKK), Divya Sanjivani Vati (DSV), ... -
Five-Decade Update on Chemopreventive and Other Pharmacological Potential of Kurarinone: a Natural Flavanone
Kumar, Shashank; Prajapati, Kumari Sunita; Shuaib, Mohd; Kushwaha, Prem Prakash; Tuli, Hardeep Singh; Singh, Atul Kumar (Frontiers Media S.A., 2021-09-27)In the present article we present an update on the role of chemoprevention and other pharmacological activities reported on kurarinone, a natural flavanone (from 1970 to 2021). To the best of our knowledge this is the first ... -
Geminin a multi task protein involved in cancer pathophysiology and developmental process: A review
Kushwaha, Prem Prakash; Rapalli, Krishna Chaitanya; Kumar, Shashank (Elsevier B.V., 2016)DNA replicates in a timely manner with each cell division. Multiple proteins and factors are involved in the initiation of DNA replication including a dynamic interaction between Cdc10-dependent transcript (Cdt1) and Geminin ... -
Green Synthesis of Bimetallic Au/Ag Nanostructures Using Aqueous Extract of Eichhornia crassipes for Antibacterial Activity
Halder, Arindom; Biswas, Rathindranath; Kushwaha, Prem Prakash; Halder, Krishna Kamal; Ahmed, Imtiaz; Singh, Harjinder; Kumar, Shashank; Haldar, Krishna Kanta (Springer, 2022-02-12)Biosynthesis of nanostructured materials is an arising feature of the interdisciplinary relationship between nanotechnology and biotechnology and acquiring consideration because of developing interest to foster ecologically ... -
Identification of cancer stemness related miRNA(s) using integrated bioinformatics analysis and in vitro validation
Prajapati, Kumari Sunita; Shuaib, Mohd; Kushwaha, Prem Prakash; Singh, Atul Kumar; Kumar, Shsahank (Springer Science and Business Media Deutschland GmbH, 2021-09-23)The stemness property of cells allows them to sustain their lineage, differentiation, proliferation, and regeneration. MicroRNAs are small non-coding RNAs known to regulate the stemness property of cells by regulating the ... -
Identification of FDA approved drugs and nucleoside analogues as potential SARS-CoV-2 A1pp domain inhibitor: An in silico study
Singh, Atul Kumar; Kushwaha, Prem Prakash; Prajapati, Kumari Sunita; Shuaib, Mohd; Gupta, Sanjay; Kumar, Shashank (Elsevier Ltd, 2020-12-19)Coronaviruses are known to infect respiratory tract and intestine. These viruses possess highly conserved viral macro domain A1pp having adenosine diphosphate (ADP)-ribose binding and phosphatase activity sites. A1pp ... -
Identification of miRNAs and related hub genes associated with the triple negative breast cancer using integrated bioinformatics analysis and in vitro approach
Shuaib, Mohd; Prajapati, Kumari Sunita; Singh, Atul Kumar; Kushwaha, Prem Prakash; Waseem, Mohammad; Kumar, Shashank (Taylor and Francis Ltd., 2021-08-13)Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype generally associated with younger women. Due to the lack of suitable drugable targets in TNBC, the microRNAs are considered as a better hope as ... -
Identification of Natural Inhibitors Against SARS-CoV-2 Drugable Targets Using Molecular Docking, Molecular Dynamics Simulation, and MM-PBSA Approach
Kushwaha, Prem Prakash; Singh, Atul Kumar; Bansal, Tanya; Yadav, Akansha; Prajapati, Kumari Sunita; Shuaib, Mohd; Kumar, Shashank (Frontiers Media S.A., 2021-08-12)The present study explores the SARS-CoV-2 drugable target inhibition efficacy of phytochemicals from Indian medicinal plants using molecular docking, molecular dynamics (MD) simulation, and MM-PBSA analysis. A total of 130 ... -
In silico identification of natural anticancer product and their efficacy in breast cancer cells and cancer stem like cells
Kushwaha, Prem Prakash (Central University of Punjab, 2020)Breast cancer is the most commonly diagnosed lethal cancer in women worldwide. Notch signaling pathway is directly linked to breast cancer recurrence and aggressiveness. Natural remedies are becoming a prime choice to ... -
Long non-coding RNA regulating androgen receptor signaling in breast and prostate cancer
Kumar, Shashank; Prajapati, Kumari Sunita; Singh, Atul Kumar; Kushwaha, Prem Prakash; Shuaib, Mohd; Gupta, Sanjay (Elsevier Ireland Ltd, 2021-02-07)The human genome transcribe an array of RNAs that do not encode proteins and may act as mediators in the regulation of gene expression. Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs consisting of more than ... -
miRNAs as Therapeutic Target in Obesity and Cancer
Prajapati, Kumari Sunita; Shuaib, Mohd; Kushwaha, Prem Prakash; Singh, Atul Kumar; Sharma, Rahul; Kumar, Shashank (Springer Singapore, 2021-07-18)MicroRNAs are small non-coding RNAs that regulate the expression of many genes. Alteration of microRNA expressions is associated with the occurrence of diseases including cancer, obesity, and obesity-related cancer. miRNAs ... -
Naphthylisoindolinone alkaloids: the first ring-contracted naphthylisoquinolines, from the tropical liana Ancistrocladus abbreviatus, with cytotoxic activity
Fayez, Shaimaa; Bruhn, Torsten; Feineis, Doris; Assi, Laurent Ak�; Kushwaha, Prem Prakash; Kumar, Shashank; Bringmann, Gerhard (Royal Society of Chemistry, 2022-10-12)The West African liana Ancistrocladus abbreviatus is a rich source of structurally most diverse naphthylisoquinoline alkaloids. From its roots, a series of four novel representatives, named ancistrobrevolines A-D (14-17) ... -
Neuroprotective and Neurorescue Mode of Action of Bacopa monnieri (L.) Wettst in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson�s Disease: An In Silico and In Vivo Study
Singh, Babita; Pandey, Shivani; Rumman, Mohammad; Kumar, Shashank; Kushwaha, Prem Prakash; Verma, Rajesh; Mahdi, Abbas Ali (Frontiers Media S.A., 2021-03-16)Ethnopharmacological Relevance: Parkinson�s disease (PD) is characterized by progressive death of dopaminergic neurons. The presently used medicines only tackle the symptoms of PD, but none makes a dent on the processes ... -
Novel potent inhibitors of Plasmodium vivax dihydrofolate reductase: An in silico antimalarial drug discovery
Pushpendra, Singh; Kushwaha, Prem Prakash; Shashank, Kumar (Association of Pharmaceutical Teachers of India, 2018)Objectives: In the present study, we targeted the dihydrofolate reductase enzyme that catalyzes the reduction of dihydrofolate to tetrahydrofolate which is required for the purines and pyrimidine synthesis. Malaria is one ... -
Phytochemicals present in Indian ginseng possess potential to inhibit SARS-CoV-2 virulence: A molecular docking and MD simulation study
Kushwaha, Prem Prakash; Singh, Atul Kumar; Prajapati, Kumari Sunita; Shuaib, Mohd; Gupta, Sanjay; Kumar, Shashank (Academic Press, 2021-05-24)Coronaviruses are deadly and contagious pathogens that affects people in different ways. Researchers have increased their efforts in the development of antiviral agents against coronavirus targeting Mpro protein (main ... -
Recent advancement to target Breast Cancer and Cancer Stem Cells
Kushwaha, Prem Prakash; Kumar, Shashank (Open Access, 2017)Breast cancer is the second most prominent reason of cancer death in women after lung cancer, and it accounts for 25.2% of all cancer in women [1]. In the US, approximately about one in eight women (12%) develop invasive ... -
Role of prostate cancer stem-like cells in the development of antiandrogen resistance
Kushwaha, Prem Prakash; Verma, Shiv; Kumar, Shashank; Gupta, Sanjay (OAE Publishing Inc., 2022-06-09)Androgen deprivation therapy (ADT) is the standard of care treatment for advance stage prostate cancer. Treatment with ADT develops resistance in multiple ways leading to the development of castration-resistant prostate ...