Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Title
Now showing items 166-185 of 272
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A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2
(American Chemical Society, 2021-11-02)The allosteric regulation of pyruvate kinase M2 (PKM2) affects the switching of the PKM2 protein between the high-activity and low-activity states that allow ATP and lactate production, respectively. PKM2, in its low ... -
A Perspective on Monoamine Oxidase Enzyme as Drug Target: Challenges and Opportunities
(2017)The monoamine oxidase (MAO) enzyme is responsible for the deamination of monoamine neurotransmitters and regulates their concentration in the central and peripheral nervous systems. Imbalance in the concentration of ... -
Pharmaceutical Industry, Academia, Regulatory Authorities and End User Collaboration in Successful Drug Discovery and Development
(Springer Singapore, 2021-02-18)This chapter reviews the literature on the various factors (time-consuming processes, regulatory requirements, high attrition rate in phase III clinical trials and decrease in RandD productivity) contributed to increase ... -
Pharmacological and chemical potential of Cassia fistula L- a critical review
(Elsevier GmbH, 2020-10-19)Cassia fistula L. (Fabaceae) is a plant species called �Aragvadha� which means �disease killer�. C. fistula consists of a large amount of medicinal properties. The plant has been used in Ayurvedic medicine since ancient ... -
Phosphate Prodrugs: An Approach to Improve the Bioavailability of Clinically Approved Drugs
(Bentham Science Publishers, 2023-02-09)The phosphate prodrug approach has emerged as a viable option for increasing the bioavailability of a drug candidate with low hydrophilicity and poor cell membrane permeability. When a phosphoric acid moiety is attached ... -
Photoprotective, antioxidant screening and new ester from dry root extracts of Potentilla atrosanguinea (Himalayan cinquefoil)
(Elsevier, 2016)In vitro photoprotective and antioxidant activities of dried aqueous-methanolic (H2O/MeOH) crude extract and ethyl acetate (EtOAc), n-butanol (n-BuOH) as well as aqueous (H2O) fractions of roots of western Himalayan plant ... -
Phytochemical Profiling and Pharmacological Evaluation of Leaf Extracts of Ruellia tuberosa L.: An In Vitro and In Silico Approach
(John Wiley and Sons Inc, 2023-08-04)The present study was designed to appraise the photoprotective, antioxidant, and antibacterial bioactivities of Ruellia tuberosa leaves extracts (RtPE, RtChl, RtEA, RtAc, RtMe, and RtHMe). The results showed that, RtHMe ... -
Plant-derived natural alkaloids as new antimicrobial and adjuvant agents in existing antimicrobial therapy
(Bentham Science Publishers, 2019)Infectious diseases, instigated by pathogenic microorganisms are the cause of numerous health problems in developing countries. Infectious diseases got a place in the list of top ten death causes worldwide. The reason ... -
Polycystic ovary syndrome: Current scenario and future insights
(Elsevier Ltd, 2023-11-05)Polycystic ovary syndrome (PCOS) prevails in approximately 33% of females of reproductive age globally. Although the root cause of the disease is unknown, attempts are made to clinically manage the disturbed hormone levels ... -
Polymeric Encapsulates of Essential Oils and Their Constituents: A Review of Preparation Techniques, Characterization, and Sustainable Release Mechanisms
(Taylor and Francis Inc., 2016)Natural polymer based encapsulation of essential oil (EO) is one of the emerging and challenging area of research in perfumery, cosmetics, flavoring agents, preservatives, therapeutics, etc. The knowledge of formulation ... -
Polymeric nanoparticles of aromatase inhibitors: A comprehensive review
(Bentham Science Publishers, 2020-09-29)Being the second most frequent cancer, breast cancer is emerging worldwide with an alarming rate, specifically in post-menopausal women. Targeted drug delivery has been in the focus for the successful treatment of breast ... -
Pore-forming proteins and their role in cancer and inflammation: Mechanistic insights and plausible druggable targets
(Elsevier Ireland Ltd, 2022-08-30)Perforin is a granular effector pore-forming protein formed in NK cells and Cytotoxic T lymphocytes. These cytotoxic proteins are part of the first-line immune defense in the human body. They ensure apoptosis of pathogen-infected ... -
Probing the molecular mechanisms of ?-synuclein inhibitors unveils promising natural candidates through machine-learning QSAR, pharmacophore modeling, and molecular dynamics simulations
(Institute for Ionics, 2023-07-18)Parkinson�s disease is characterized by a multifactorial nature that is linked to different pathways. Among them, the abnormal deposition and accumulation of ?-synuclein fibrils is considered a neuropathological hallmark ... -
Promising targets in anti-cancer drug development: Recent updates
(Bentham Science Publishers B.V., 2017)Cancer is a multifactorial disease and its genesis and progression are extremely complex. The biggest problem in the anticancer drug development is acquiring of multidrug resistance and relapse. Classical chemotherapeutics ... -
PROTAC�ing oncoproteins: targeted protein degradation for cancer therapy
(BioMed Central Ltd, 2023-03-30)Molecularly targeted cancer therapies substantially improve patient outcomes, although the durability of their effectiveness can be limited. Resistance to these therapies is often related to adaptive changes in the target ... -
Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters
(Springer, 2020)Chronic fatigue syndrome (CFS) is a disorder characterized by persistent and relapsing fatigue along with long-lasting and debilitating fatigue, myalgia, cognitive impairment, and many other common symptoms. The present ... -
Pyrazoloquinazolines: Synthetic strategies and bioactivities
(2015)Numerous N-heterocycles are indisputably evidenced to exhibit myriad biological activities. In the recent past, attempts made to condense the various heterocycles have resulted in derivatives possessing better bioactivities. ... -
Pyrimidine containing epidermal growth factor receptor kinase inhibitors: Synthesis and biological evaluation
(Blackwell Publishing Ltd, 2017)Structure-based design and synthesis of pyrimidine containing reversible epidermal growth factor receptor (EGFR) inhibitors 1a?d are reported. The compounds (1a?d) inhibited the EGFR kinase activity in vitro with IC50 range ... -
Pyrimidine-fused derivatives: Synthetic strategies and medicinal attributes
(Bentham Science Publishers B.V., 2016)Pyrimidine-fused derivatives traits the inextricable part of DNA and RNA, exhibit indispensable role in numerous biological processes, possessing momentous chemical and biological importance. Pyrimidine-condensed derivatives ... -
Pyrrolo- and pyridomorphinans: Non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists
(Elsevier, 2014)Opioid ligands have found use in a number of therapeutic areas, including for the treatment of pain and opiate addiction (using agonists) and alcohol addiction (using antagonists such as naltrexone and nalmefene). The ...