Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Title
Now showing items 206-225 of 272
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Regulation of thymidylate synthase: an approach to overcome 5-FU resistance in colorectal cancer
(Springer, 2022-10-29)Thymidylate synthase is the rate-limiting enzyme required for DNA synthesis and overexpression of this enzyme causes resistance to cancer cells. Long treatments with 5-FU cause resistance to Thymidylate synthase targeting ... -
Relay tricyclic Pd (ii)/Ag (i) catalysis: design of a four-component reaction driven by nitrene-transfer on isocyanide yields inhibitors of EGFR.
(Royal Society of Chemistry, 2018)Synthesis of pyrazolo[1,5-c]quinazolines from four easily available precursors is presented through a one-pot tricyclic Pd(II)/Ag(I) relay catalysis. The bimetallic relay cascade forges five new chemical bonds by concatenating ... -
Research progress on 2,4-thiazolidinedione and 2-thioxo-4-thiazolidinone analogues as aldose reductase inhibitors
(Elsevier B.V., 2022-07-18)Diabetes-associated complications are a major global health concern. In diabetics, the increased accumulation of sorbitol, produced via over activated polyol pathway, from glucose by the action of aldose reductase (AR, ... -
A Review of Phytoconstituents as Antibacterial Agents
(Bentham Science Publishers, 2022-08-04)Background bacteria cause various infectious diseases and cause millions of deaths each year. Bacteria are broadly classified based on the phenotypic and genotypic systems. Bacteria cause resistance mainly by Plasmids, ... -
A Review of Pyridine and Pyrimidine Derivatives as Anti-MRSA Agents
(Bentham Science Publishers, 2022-07-06)Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a Gram-positive strain whose resistance against existing antibiotics is a significant concern for researchers across the globe. Gram-positive infections, ... -
A Review on Molecular Mechanism of Flavonoids as Antidiabetic Agents
(Bentham Science, 2019)The development of drugs possessing anti-diabetic activities is a long pursued goal in drug discovery. It has been shown that deregulated insulin mediated signaling, oxidative stress, obesity, and β-cell dysfunction are ... -
A review on pharmacophoric designs of antiproliferative agents
(Birkhauser Boston, 2015)Past few decades have witnessed the dawn of new diseases in which cancer is a major problem and the race ensued to eradicate cancer by charting out various effective therapeutic regimens. Circumventing resistance issues ... -
A review on quinoline derivatives as anti-methicillin resistant Staphylococcus aureus (MRSA) agents
(BioMed Central Ltd., 2020)Methicillin Resistant Staphylococcus aureus (MRSA) consists of strains of S. aureus which are resistant to methicillin. The resistance is due to the acquisition of mecA gene which encodes PBP2a unlike of any PBPs normally ... -
A review on quinoline derived scaffolds as anti-HIV agents
(Bentham Science Publishers, 2019)After restricting the proliferation of CD4+T cells, Human Immunodeficiency Virus (HIV), infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS). This demands the vigorous need of suitable ... -
A review on quinoline derived scaffolds as Anti-HIV Agents.
(Bentham Science, 2018)After restricting the proliferation of CD4+T cells, Human Immunodeficiency Virus (HIV), infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS). This demands the vigorous need of suitable ... -
A review on reported phytochemicals as druggable leads with antimalarial potential
(Springer, 2023-07-04)The science and practice of drug discovery and development is primarily benefitted from the natural sources. The chemistry of natural products has inspired medicinal chemists to develop and design various therapeutic ... -
Rhodanine derivatives: An insight into the synthetic and medicinal perspectives as antimicrobial and antiviral agents
(John Wiley and Sons Inc, 2022-11-30)Rhodanine or 2-Thioxothiazolidin-4-one is a privileged heterocyclic compound offering a wide opportunity for structural modification, lead development, and modification. It is one of the highly decorated scaffolds in the ... -
Role of Collagen Regulators in Cancer Treatment: A Comprehensive Review
(Bentham Science Publishers, 2022-05-01)Collagen is the most important structural protein and also the main component of the extra-cellular matrix (ECM). It plays a role in tumor progression. Collagen can be regulated by altering its biosynthesis pathway through ... -
Role of genomic alterations in HER2 positive breast carcinoma: Focus on susceptibility and trastuzumab-therapy
(Bentham Science Publishers B.V., 2017)Background: Breast cancer is the most frequently diagnosed life-threatening malignancy among women, across the globe. HER2 positive is a distinct breast cancer subtype, on account of its unique biology and physiological ... -
Role of peroxisome proliferator-activated receptor gamma (Ppar?) in different disease states: Recent updates
(Bentham Science Publishers, 2020-07-17)Peroxisome proliferator-activated receptor (PPAR), a ligand dependant transcription factor, is a member of the nuclear receptor superfamily. PPAR exists in three isoforms i.e. PPAR alpha (PPAR?), PPAR beta (PPAR?), and ... -
Selection of active antiviral compounds against COVID-19 disease targeting coronavirus endoribonuclease nendou/NSP15 via ligand-based virtual screening and molecular docking
(Bentham Science Publishers, 2020-12-15)Background: The rapid spread of SARS-CoV-2 has caused havoc and panic among individuals, which has further worsened due to the unavailability of a proven drug(s) regime. Objective: The current work involves drug repurposing ... -
Selective Estrogen receptor degraders (SERDs) for the treatment of breast cancer: An overview
(Elsevier Masson s.r.l., 2023-05-04)Discovery of SERDs has changed the direction of anticancer research, as more than 70% of breast cancer cases are estrogen receptor positive (ER+). Therapies such as selective estrogen receptor modulators (SERM) and aromatase ... -
Selective Estrogen Receptor Modulators (SERMs) for the treatment of ER+ breast cancer: An overview
(Elsevier B.V., 2022-08-02)Breast cancer is a major threat to women's lives throughout the world. Hormone-dependent or estrogen-receptor positive (ER+) breast cancer accounts for more than 80% of all instances. Selective Estrogen Receptor Modulators ... -
Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/ Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity
(ACS Publications, 2014)Emerging clinical and preclinical evidence suggests that a compound displaying high affinity for μ, κ, and δ opioid (MOP, KOP, and DOP) receptors and antagonist activity at each, coupled with moderate affinity and efficacy ... -
Seven-membered ring fused pyrimidine-based derivatives and their biological properties
(Elsevier, 2022-10-14)In the chapter, the synthesis along-with the biological importance of seven-membered ring fused pyrimidine-based derivatives has been discussed, where the seven-membered rings may consist of heteroatoms such as sulfur, ...