Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Author "Husbands, Stephen M."
Now showing items 1-3 of 3
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C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors
Cueva, Juan Pablo; Roche, Christopher; Ostovar, Mehrnoosh; Kumar, Vinod; Clark, Mary J.; Hillhouse, Todd M.; Lewis, John W.; Traynor, John R.; Husbands, Stephen M. (ACS Publications, 2015)Buprenorphine is a successful analgesic and treatment for opioid abuse, with both activities relying on its partial agonist activity at mu opioid receptors. However, there is substantial interest in its activities at the ... -
Pyrrolo- and pyridomorphinans: Non-selective opioid antagonists and delta opioid agonists/mu opioid partial agonists
Kumar, Vinod; Clark, Mary J.; Traynor, J. R.; Lewis, J. W.; Husbands, Stephen M. (Elsevier, 2014)Opioid ligands have found use in a number of therapeutic areas, including for the treatment of pain and opiate addiction (using agonists) and alcohol addiction (using antagonists such as naltrexone and nalmefene). The ... -
Selectively Promiscuous Opioid Ligands: Discovery of High Affinity/ Low Efficacy Opioid Ligands with Substantial Nociceptin Opioid Peptide Receptor Affinity
kumar, Vinod; Ridzwan, Irna E.; Grivas, Konstantinos; Lewis, John W.; Clark, Mary J.; Meurice, Claire; Jimenez-Gomez, Corina; Pogozheva, Irina; Mosberg, Henry; Traynor, John R.; Husbands, Stephen M.; (ACS Publications, 2014)Emerging clinical and preclinical evidence suggests that a compound displaying high affinity for μ, κ, and δ opioid (MOP, KOP, and DOP) receptors and antagonist activity at each, coupled with moderate affinity and efficacy ...