Browsing Pharmaceutical Sciences and Natural Products-Research Publications by Author "Jain, Akhlesh Kumar"
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Dual Aromatase-Sulphatase Inhibitors (DASIs) for the Treatment of Hormone Dependent Breast Cancer
Banjare, Laxmi; Jain, Akhlesh Kumar; Thareja, Suresh (Bentham Science Publishers, 2021-01-19)Breast cancer is the most frequently diagnosed cancer in women and the second most common form of cancer, causing death after lung cancer, all across the globe at an alarming rate. The level of estrogens in breast cancer ... -
Flavonoids as promising anticancer agents: an in silico investigation of ADMET, binding affinity by molecular docking and molecular dynamics simulations
Biharee, Avadh; Yadav, Arpita; Jangid, Kailash; Singh, Yogesh; Kulkarni, Swanand; Sawant, Devesh M.; Kumar, Pradeep; Thareja, Suresh; Jain, Akhlesh Kumar (Taylor and Francis Ltd., 2022-09-27)Cancer is one of the most concerning diseases to humankind. Various treatment strategies are being employed for its treatment, out of which use of natural products is an essential one. Flavonoids have proven to be promising ... -
Mannose conjugated starch nanoparticles for preferential targeting of liver cancer
Jain, Akhlesh Kumar; Sahu, Hitesh; Mishra, Keerti; Thareja, Suresh (Bentham Science Publishers, 2020-09-04)Aim: To design D-Mannose conjugated 5-Fluorouracil (5-FU) loaded Jackfruit seed starch nanoparticles (JFSSNPs) for site-specific delivery. Background: Liver cancer is the third leading cause of death in the world and the ... -
Microsponges as Drug Delivery System: Past, Present, and Future Perspectives
Biharee, Avadh; Bhartiya, Sudha; Yadav, Arpita; Thareja, Suresh; Jain, Akhlesh Kumar (Bentham Science Publishers, 2023-04-04)Microsponges are polymeric delivery devices composed of porous microspheres that range in size from 5 to 300 micrometers. These have been explored for biomedical applications such as targeted drug deliv-ery, transdermal ... -
Multifaceted 3D-QSAR analysis for the identification of pharmacophoric features of biphenyl analogues as aromatase inhibitors
Banjare, Laxmi; Singh, Yogesh; Verma, Sant Kumar; Singh, Atul Kumar; Kumar, Pradeep; Kumar, Shashank; Jain, Akhlesh Kumar; Thareja, Suresh (Taylor and Francis Ltd., 2021-12-29)Aromatase, a cytochrome P450 enzyme, is responsible for the conversion of androgens to estrogens, which fuel the multiplication of cancerous cells. Inhibition of estrogen biosynthesis by aromatase inhibitors (AIs) is one ... -
De novo designing, assessment of target affinity and binding interactions against aromatase: Discovery of novel leads as anti-breast cancer agents
Verma, Sant Kumar; Ratre, Pooja; Jain, Akhlesh Kumar; Liang, Chengyuan; Gupta, Ghanshyam Das; Thareja, Suresh (Springer, 2020-11-13)Aromatase inhibitors (AIs) have been emerged as promising anti-cancer agents for the treatment of hormone dependent breast cancer (HDBC) in women because of their excellent ability of inhibiting oestrogen synthesis. Here, ... -
Rational design and synthesis of novel biphenyl thiazolidinedione conjugates as inhibitors of protein tyrosine phosphatase 1B for the management of type 2 diabetes
Thareja, Suresh; Verma, Sant Kumar; Jain, Akhlesh Kumar; Kumar, Manoj; Bhardwaj, Tilak Raj (Elsevier B.V., 2022-11-12)To achieve the unmet discovery of protein tyrosine phosphatase 1B (PTP1B) inhibitors, we have rationally designed novel biphenyl thiazolidinedione conjugates (8a-n). The designed molecules were found fit on in silico ... -
Recent Advancement of Polymersomes as Drug Delivery Carrier
Singh, Kuldeep; Biharee, Avadh; Vyas, Amber; Thareja, Suresh; Jain, Akhlesh Kumar (Bentham Science Publishers, 2022-04-14)Background: Biomedical applications of polymersomes have been explored, including drug and gene delivery, insulin delivery, hemoglobin delivery, the delivery of anticancer agents, and various diagnostic purposes. Objectives: ...